Results 151 to 160 of about 5,992,931 (291)
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Shoulder Rotation Test: A New Test for Discriminating Between Functional and Structural Weakness. [PDF]
Kanbayashi T, Sonoo M.
europepmc +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
A Practical Identifiability Criterion Leveraging Weak-Form Parameter Estimation. [PDF]
Heitzman-Breen N, Dukic V, Bortz DM.
europepmc +1 more source
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
A systemic pharmacovigilance assessment of ophthalmic atropine: signal detection and clinical prioritization from the FAERS database. [PDF]
Xu Z +10 more
europepmc +1 more source
Are the Weak Channels Really Weak?
The transfer probabilities for 20Ne + 90Zr and 20Ne + 92Zr at energies near the Coulomb barrier were measured. This quantity turned out to be very similar for both Zr isotopes and does not explain the observed differences in the barrier height distributions for these ...
Piasecki, E. +25 more
openaire +3 more sources
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source

