Results 41 to 50 of about 2,466,381 (317)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Control of femtosecond multi-filamentation in glass by designable patterned optical fields

open access: yesAIP Advances, 2016
We present a scheme for realizing femtosecond multi-filamentation with designable quantity and locations of filaments, based on the control of multi-focal spots formed by patterned optical fields (POFs) composed of multiple individual optical fields ...
Ping-Ping Li   +8 more
doaj   +1 more source

Propagation and Focusing Properties of Vortex Beams Based on Light Ray Tracing

open access: yesFrontiers in Physics, 2022
By using the ray-tracing method based on geometric optics, we studied the propagating and focusing characteristics of vortex beams with a top-hat intensity distribution.
Meng-Qiang Cai   +4 more
doaj   +1 more source

Weak comonotonicity

open access: yesEuropean Journal of Operational Research, 2018
The classical notion of comonotonicity has played a pivotal role when solving diverse problems in economics, finance, and insurance. In various practical problems, however, this notion of extreme positive dependence structure is overly restrictive and sometimes unrealistic.
Ruodu Wang, Ricardas Zitikis
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

OMMR: Co-registration toolbox of OPM-MEG and MRI

open access: yesFrontiers in Neuroscience, 2022
Magnetoencephalography (MEG) based on optically pumped magnetometers (OPM-MEG) has shown better flexibility in sensor configuration compared with the conventional superconducting quantum interference devices-based MEG system while being better suited for
Fuzhi Cao   +19 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

CUBIC HYPER KU-IDEALS

open access: yesJournal of New Theory, 2017
–It is known that, the concept of hyper KU-algebras is a generalization of KU-algebras. In this paper, we define cubic (strong, weak,s-weak) hyper KU-ideals of hyper KU-algebras and related properties are ...
Samy Mohammed Mostafa   +2 more
doaj  

Coin Paradox Spin–Orbit Interaction Enhances Magneto-Optical Effect and Its Application in On-Chip Integrated Optical Isolator

open access: yesNanoscale Research Letters, 2021
We designed a simple on-chip integrated optical isolator made up of a metal–insulator–metal waveguide and a disc cavity filled with magneto-optical material to enhance the transverse magneto-optical effect through the coin paradox spin–orbit interaction (
Hao Hu   +11 more
doaj   +1 more source

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