Results 41 to 50 of about 943,889 (286)
Modeling of crack propagation in weak snowpack layers using the discrete element method [PDF]
The Cryosphere, 2015 Dry-snow slab avalanches are generally caused by a sequence of fracture processes including (1) failure initiation in a weak snow layer underlying a cohesive slab, (2) crack propagation within the weak layer and (3) tensile fracture through the slab ...
J. Gaume +4 more
doaj +1 more source
Buildings, 2023 The western region of China is rich in hydropower resources and characterized by unique geological conditions. For the construction or planned construction of high dams in this region, different types of cover layers are formed due to special geological ...
Mengdie Zhao +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Stress Concentrations in Weak Snowpack Layers and Conditions for Slab Avalanche Release
Geophysical Research Letters, 2018 Dry‐snow slab avalanches release due to the formation of a crack in a weak layer buried below cohesive snow slabs, followed by rapid crack propagation.
J. Gaume +3 more
doaj +1 more source
Lithosphere, 2022 The 2008 Wenchuan Ms 8.0 earthquake triggered the Daguangbao (DGB) landslide, of which the shear surface belongs to a thrust bedding fault 400 m below the carbonate slope.
Shenghua Cui +4 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Study on instability mode of double weak layer burnt rock slope
Meikuang Anquan, 2022 In order to study the failure mode of double weak layer slope of burnt rock in opencast coal mine, the failure and deformation characteristics of the slope were analyzed by means of FLAC3D numerical simulation, and the mechanical model of the slope was ...
LI Wei
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Few layer graphene on SiC, pyrolitic graphite and graphene: a Raman scattering study
, 2007 The results of micro-Raman scattering measurements performed on three different ``graphitic'' materials: micro-structured disks of highly oriented pyrolytic graphite, graphene multi-layers thermally decomposed from carbon terminated surface of 4H-SiC and
A. Mahmood +7 more
core +4 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source