Results 41 to 50 of about 14,610 (258)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier +11 more
wiley +1 more source
A cellular-automata model for assessing the sensitivity of the street network to natural terrain
Annals of GIS, 2021 Natural and human-made features are not exclusive in settlements but interact across time and space, placing the context in constant evolution. The purpose of this paper is to search for the influence of terrain, a natural feature, on the configuration ...
Jeeno Soa George +2 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
An optimal capacity allocation method for integrated energy systems considering uncertainty
AIP Advances, 2023 The randomness and fluctuation of wind power output will cause certain waste in capacity allocation of integrated energy system. Therefore, a robust chance constrained optimization model is proposed to solve the shortcomings of the traditional model in ...
Yuliang Zhang, Jianguo Zhang, Yujie Chen
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Stochastic Evolution Game of Knowledge Sharing in the Infrastructure PPP Supply Chain Network
Complexity, 2020 Due to the complexity and randomness of environmental change, the knowledge-sharing behavior of members in the PPP supply chain will be affected by random disturbance factors. Traditional evolutionary game models cannot describe this effect.
Huimin Li +4 more
doaj +1 more source
The impossibility of extending random dictatorship to weak preferences [PDF]
Economics Letters, 2016 Random dictatorship has been characterized as the only social decision scheme that satisfies efficiency and strategyproofness when individual preferences are strict. We show that no extension of random dictatorship to weak preferences satisfies these properties, even when significantly weakening the required degree of strategyproofness.
Florian Brandl +2 more
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source