Results 51 to 60 of about 15,802 (259)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
A cellular-automata model for assessing the sensitivity of the street network to natural terrain
Annals of GIS, 2021 Natural and human-made features are not exclusive in settlements but interact across time and space, placing the context in constant evolution. The purpose of this paper is to search for the influence of terrain, a natural feature, on the configuration ...
Jeeno Soa George +2 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
The impossibility of extending random dictatorship to weak preferences [PDF]
Economics Letters, 2016 Random dictatorship has been characterized as the only social decision scheme that satisfies efficiency and strategyproofness when individual preferences are strict. We show that no extension of random dictatorship to weak preferences satisfies these properties, even when significantly weakening the required degree of strategyproofness.
Florian Brandl +2 more
openaire +4 more sources
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
An optimal capacity allocation method for integrated energy systems considering uncertainty
AIP Advances, 2023 The randomness and fluctuation of wind power output will cause certain waste in capacity allocation of integrated energy system. Therefore, a robust chance constrained optimization model is proposed to solve the shortcomings of the traditional model in ...
Yuliang Zhang, Jianguo Zhang, Yujie Chen
doaj +1 more source
Weak Localization of Light in Superdiffusive Random Systems [PDF]
Physical Review Letters, 2012 Lévy flights constitute a broad class of random walks that occur in many fields of research, from animal foraging in biology, to economy to geophysics. The recent advent of Lévy glasses allows to study Lévy flights in controlled way using light waves.
M. Burresi +5 more
openaire +6 more sources
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
The Stochastic Evolution Game of Knowledge Sharing in the Infrastructure PPP Supply Chain Network
Complexity, 2020 Due to the complexity and randomness of environmental change, the knowledge-sharing behavior of members in the PPP supply chain will be affected by random disturbance factors. Traditional evolutionary game models cannot describe this effect.
Huimin Li +4 more
doaj +1 more source