Results 141 to 150 of about 10,780,423 (379)

Generalized Weak Solutions

open access: yes, 2021
Eduard Feireisl   +3 more
openaire   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

Model and analysis for quasistatic frictional contact of a 2D elastic bar

open access: yesElectronic Journal of Differential Equations, 2018
This article constructs and analyzes a mathematical model that describes the quasistatic evolution of a 2D elastic bar that may come in frictional contact with a deformable foundation.
Mircea Sofonea, Meir Shillor
doaj  

Multiplicity Results of Solutions to the Fractional p-Laplacian Problems of the Kirchhoff–Schrödinger–Hardy Type

open access: yesMathematics
This paper is devoted to establishing multiplicity results of nontrivial weak solutions to the fractional p-Laplacian equations of the Kirchhoff–Schrödinger type with Hardy potentials.
Yun-Ho Kim
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

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