Results 51 to 60 of about 5,114,170 (301)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Electronic Journal of Differential Equations, 1998 We study the initial value problem for the 3-D Euler equation when the fluid is inviscid and incompressible, and flows with axisymmetry and without swirl.
Dongho Chae, Oleg Yu Imanuvilov
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Anisotropic singularity of solutions to elliptic equations in a measure framework
Electronic Journal of Differential Equations, 2015 In this article we study the weak solutions of elliptic equation $$\displaylines{ -\Delta u=2\frac{\partial \delta_0}{\partial \nu }\quad \text{in }\Omega,\cr u=0\quad \text{on }\partial\Omega, }$$ where $\Omega$ is an open bounded $C^2$ domain ...
Wanwan Wang, Huyuan Chen, Jian Wang
doaj
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Remind Solution (Australia) Brain Booster Benefits!
, 2022 Henceforth, the audit here has the intense Remind Solution, which is exceptional and helps upgrade your memory, in contrast to other memory items. Peruse the survey about Remind Solution, which could assist Remind Solution you with reestablishing your ...
Remind Solution
core +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Existence of weak solutions for a non-homogeneous solidification mathematical model
Electronic Journal of Differential Equations, 2006 This article studies the existence of weak solutions for a stationary non-homogeneous system of equations describing the solidification process of a binary alloy confined to a regular bounded domain in $R^3$ and having mixed boundary conditions.
Elva Ortega-Torres, Mario M. Duran
doaj
On the regularity of weak solutions to $H$-systems
Rendiconti Lincei, Matematica e Applicazioni, 2007 In this paper we prove that every weak solution to the H -surface equation is locally bounded, provided the prescribed mean curvature H satisfies a suitable ...
openaire +5 more sources