Results 71 to 80 of about 2,506,197 (280)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Electronic Journal of Differential Equations, 2017 In this work, we are interested in the mathematical model of reaction diffusion systems. The originality of our study is to work with concentrations appearing in reactors together with measure initial data.
Nour Eddine Alaa, Fatima Aqel
doaj
St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2019 To verify the solution of a typical Crocco boundary problem, a numerical experiment was performed using an implicit second-order difference scheme. It is shown that a numerical solution approximates a weak solution of a typical Crocco limit problem ...
Petrichenko Mikhail, Kotov Eugene
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Weak solutions for weak turbulence models in electrostatic plasmas
, 2023 The weak turbulence model, also known as the quasilinear theory in plasma physics, has been a cornerstone in modeling resonant particle-wave interactions in plasmas. This reduced model stems from the Vlasov-Poisson/Maxwell system under the weak turbulence assumption, incorporating the random phase approximation and ergodicity.
Huang, Kun, Gamba, Irene M.
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Nonexistence of solutions results for certain fractional differential equations
Mathematical Modelling and Analysis, 2011 This paper is meant to establish sufficient conditions for the nonexistence of weak solutions to nonlinear fractional diffusion equation in space and time with nonlinear convective term. The Fujita exponent is determined.
Mohamed Berbiche
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A problem with dynamical boundary condition for a one-dimensional hyperbolic equation
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2020 In this paper, we consider a problem with dynamical boundary conditions for a hyperbolic equation. The dynamical boundary condition is a convenient method to take into account the presence of certain damper when fixing the end of a string or a beam ...
Aleksandr Borisovich Beylin +1 more
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Weak solutions for p-Laplacian equation
Advances in Nonlinear Analysis, 2012 In this work we consider the p-Laplacian type parabolic equation with Dirichlet boundary condition and establish the existence of weak solutions using Leray–Schauder's fixed point theorem and semi-discretization process.
Bhuvaneswari Venkatasubramaniam +2 more
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