Results 71 to 80 of about 5,114,170 (301)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

On the Weak Solution to a Fractional Nonlinear Schrödinger Equation [PDF]

open access: yes, 2014
We obtain the existence of a global weak solution to a fractional nonlinear Schrödinger equation by the Galerkin method. Its uniqueness is also discussed.
Xiaofeng Wang, Zheng-an Yao, Zujin Zhang
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

On regularity criteria of a weak solution to the three-dimensional magnetohydrodynamics equations in Lorentz space

open access: yes, 2018
We give a weak-Lp Serrin-type regularity criterion for a weak solution to the three-dimensional magnetohydrodynamics equations in a bounded domain Ω ⊂ ℝ3.
Jae-Myoung Kim
core   +1 more source

On the Weak Solution of a Semilinear Boundary Value Problem without the Landesman-Lazer Condition [PDF]

open access: yes, 2011
We prove the existence of weak solution to a semilinear boundary value problem without the Landesman-Lazer ...
Sikiru Adigun Sanni
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Nonnegative weak solution to the degenerate viscous Cahn–Hilliard equation [PDF]

open access: yes
The Cahn–Hilliard equation is a widely used model for describing phase separation processes in a binary mixture. In this paper, we investigate the viscous Cahn–Hilliard equation with a degenerate, phase-dependent mobility. We define the concept of a weak
Toai Luong
core   +2 more sources

Regularity criteria for weak solutions to 3D incompressible MHD equations with Hall term

open access: yesElectronic Journal of Differential Equations, 2018
We study the regularity conditions for a weak solution to the incompressible 3D magnetohydrodynamic equations with Hall term in the whole space R^3. In particular, we show the regularity criteria in view of gradient vectors in various spaces.
Jae-Myoung Kim
doaj  

Pushing the Limits of Characterising a Weak Halogen Bond in Solution

open access: yes, 2021
Detection and characterisation of very weak, non-covalent interactions in solution is inherently challenging. Low affinity, short complex lifetime and a constant battle against entropy brings even the most sensitive spectroscopic methods to their knees ...
Erdélyi, Máté   +5 more
core   +1 more source

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