Results 81 to 90 of about 5,114,170 (301)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

On the nonuniqueness of weak solution of the Euler equation [PDF]

open access: yesCommunications on Pure and Applied Mathematics, 1996
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Uniqueness of entropy solutions to nonlinear elliptic-parabolic problems

open access: yesElectronic Journal of Differential Equations, 2007
We study the Cauchy problem associated with the nonlinear elliptic - parabolic equation $$ b(u)_{t}-a(u,varphi(u)_x)_x=f. $$ We prove an $L^{1}$-contraction principle and hence the uniqueness of entropy solutions, under rather general assumptions ...
Hamidou Toure, Stanislas Ouaro
doaj  

BOUNDED WEAK SOLUTION FOR THE HAMILTONIAN SYSTEM

open access: yesKorean Journal of Mathematics, 2013
Summary: We investigate the bounded weak solutions for the Hamiltonian system with bounded nonlinearity decaying at the origin and periodic condition. We get a theorem which shows the existence of the bounded weak periodic solution for this system. We obtain this result by using variational method, critical point theory for indefinite functional.
Choi, Q-Heung, Jung, Tacksun
openaire   +3 more sources

SDE WEAK APPROXIMATION LIBRARY (SDE WA) (VERSION 1.0) [PDF]

open access: yes
In application of mathematical finance to practical problems, weak approximation of stochastic differential equations (SDEs) is one of the most important themes.In probabilistic approach to this problem, the Euler-Maruyama scheme which is a first-order ...
Mariko Ninomiya
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

A Note on Continuity of Solution Set for Parametric Weak Vector Equilibrium Problems [PDF]

open access: yes, 2015
We consider the parametric weak vector equilibrium problem. By using a weaker assumption of Peng and Chang (2014), the sufficient conditions for continuity of the solution mappings to a parametric weak vector equilibrium problem are established. Examples
Rabian Wangkeeree, Pakkapon Preechasilp
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

open access: yesMolecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau   +9 more
wiley   +1 more source

Weak solution of a continuum model for vicinal surface in the attachment-detachment-limited regime [PDF]

open access: yes, 2016
We study in this work a continuum model derived from 1D attachment-detachment-limited (ADL) type step flow on vicinal surface, $ u_t=-u^2(u^3)_{hhhh}$, where $u$, considered as a function of step height $h$, is the step slope of the surface. We formulate
Gao, Yuan   +8 more
core   +1 more source

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