Results 101 to 110 of about 11,044,020 (324)

On asymptotic behavior of global solutions for hyperbolic hemivariational inequalities

Electronic Journal of Differential Equations, 2006
In this paper we study the existence of global weak solutions for a hyperbolic differential inclusion with a discontinuous and nonlinear multi-valued term. Also we investigate the asymptotic behavior of solutions.
Jong Yeoul Park, Sun Hye Park
doaj  

Parabolic Harnack inequality for time-dependent non-symmetric Dirichlet forms [PDF]

, 2016
In the context of a metric measure Dirichlet space satisfying volume doubling and Poincar\'e inequality, we prove the parabolic Harnack inequality for weak solutions of the heat equation associated with local nonsymmetric bilinear forms.
Lierl, Janna, Saloff-Coste, Laurent
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Weak solutions for parabolic equations with p(x)-growth

Electronic Journal of Differential Equations, 2016
In this article we study nonlinear parabolic equations with p(x)-growth in the space $W^{1,x}L^{p(x)}(Q)\cap L^\infty(0,T; L^2(\Omega))$. By using the method of parabolic regularization, we prove the existence and uniqueness of weak solutions for the
Ning Pan, Binlin Zhang, Jun Cao
doaj  

On a class of superlinear nonlocal fractional problems without Ambrosetti–Rabinowitz type conditions

Electronic Journal of Qualitative Theory of Differential Equations, 2019
In this note, we deal with the existence of infinitely many solutions for a problem driven by nonlocal integro-differential operators with homogeneous Dirichlet boundary conditions \begin{equation*} \begin{cases} -\mathcal{L}_{K}u=\lambda f(x,u), &
Qing-Mei Zhou
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Weak solutions for a viscous p-Laplacian equation

Electronic Journal of Differential Equations, 2003
In this paper, we consider the pseudo-parabolic equation $ u_t-kDelta u_t=mathop{ m div}(| abla u|^{p-2} abla u)$. By using the time-discrete method, we establish the existence of weak solutions, and also discuss the uniqueness.
Changchun Liu
doaj  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Stability Properties of Distributional Solutions for Nonlinear Viscoelastic Wave Equations with Variable Exponents

Axioms
A system of nonlinear wave equations in viscoelasticity with variable exponents is considered. It is assumed that the kernel included in the integral term of the equations depends on both the time and the spatial variables.
Mouhssin Bayoud, Mohamed Karek, Khaled Zennir, Keltoum Bouhali, Loay Alkhalifa   +4 more
doaj   +1 more source