Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
Existence and blow up for viscoelastic hyperbolic equations with variable exponents
Communications in Analysis and MechanicsIn this article, we consider a nonlinear viscoelastic hyperbolic problem with variable exponents. By using the Faedo$ - $Galerkin method and the contraction mapping principle, we obtain the existence of weak solutions under suitable assumptions on the ...
Ying Chu, Bo Wen, Libo Cheng
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Harnack’s inequality and Hölder continuity for weak solutions of degenerate quasilinear equations with rough coefficients [PDF]
, 2015 Dario D. Monticelli +2 more
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Weak solutions of the porous medium equation in a cylinder [PDF]
, 1993 Björn E. J. Dahlberg, Carlos E. Kenig
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A Solution to protodeborylation problem: weak base-promoted direct cross-coupling of naphthalene-1,8-diaminato-substituted arylboron compounds [PDF]
, 2023 Kazuki Tomota +5 more
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SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
A nonlinear wave equation with a nonlinear integral equation involving the boundary value
Electronic Journal of Differential Equations, 2004 We consider the initial-boundary value problem for the nonlinear wave equation $$displaylines{ u_{tt}-u_{xx}+f(u,u_{t})=0,quad xin Omega =(0,1 ...
Thanh Long Nguyen, Tien Dung Bui
doaj
On weak solutions of semilinear hyperbolic-parabolic equations
International Journal of Mathematics and Mathematical Sciences, 1996 In this paper we prove the existence and uniqueness of weak solutions of the mixed problem for the nonlinear hyperbolic-parabolic equation (K1(x,t)u′)′+K2(x,t)u′+A(t)u+F(u)=f with null Dirichlet boundary conditions and zero initial data, where F(s) is a
Jorge Ferreira
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