Results 31 to 40 of about 127,652 (265)

TIRE WEAR MODELING [PDF]

Transport Problems, 2017
On the basis of a known relationship, an enhanced model for specific tire wear per kilometer has been developed. It is appropriate for practical use - for evaluation of the influence of different factors. Two types of experiments have been carried out with a testing device - one without sideslip, but with a known longitudinal slip, and the other one ...
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Prediction of Abrasive and Impact Wear Due to Multi-Shaped Particles in a Centrifugal Pump via CFD-DEM Coupling Method

Energies, 2021
Since solid particles suspended in the fluid can cause wear in centrifugal pumps, intensive attention has been focused on the numerical prediction for the wear of flow parts in centrifugal pumps.
Cheng Tang, You-Chao Yang, Peng-Zhan Liu, Youn-Jea Kim   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Numerical simulation of multiphase flow and prediction of sediment wear in a large Pelton turbine

Energy Science & Engineering
The problem of sediment wear presents a significant challenge for hydraulic turbines operating in sediment‐rich rivers, particularly for high‐head Pelton turbines.
Mengjun Qin, Zhishun Yu, Baofu Wu, Jiayang Pang, Dengyun Jiang, Haiku Zhang, Jitao Liu, Hong Hua, Xiaobing Liu   +8 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Wear Prediction and Visual Decision Support of Drop Forged Rivetless Chain for Conveyors

Jixie chuandong, 2023
In order to accurately detect, predict and maintain the wear condition of drop forged rivetless chain for conveyors, the methods of wear prediction and active maintenance are developed based on gray model and visual decision support.
Liu Manxian, Xu Zijia, Shen Xujia, Li Xiaodong, Zhang Zhijun, Yang Yi   +5 more
doaj  

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Effect of Friction Model Type on Tool Wear Prediction in Machining

Machines
One of the key measures of cutting tool efficiency in machining processes is tool wear. In recent decades, numerical modeling of this phenomenon—primarily through finite element cutting models—has gained increasing importance.
Michael Storchak, Oleksandr Melnyk, Yaroslav Stepchyn, Oksana Shyshkova, Andrii Golubovskyi, Oleksandr Vozniy   +5 more
doaj   +1 more source