Results 41 to 50 of about 875,844 (360)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effects of Hot Extrusion on the Microstructure and Wear Properties of A380-Yb Alloy

Metals
A380-Yb (Ytterbium) alloy was prepared by the ultrasonic melting casting method, and effects of hot extrusion on the microstructure and wear properties of the alloy were studied.
Xiaohu Ji, Junjie Xiong, Wenle Guan, Yuxi Qi, Lihua Zhou, Heng Li   +5 more
doaj   +1 more source

Predicting wear of UHMWPE: Decreasing wear rate following a change in direction [PDF]

Wear, 2011
Abstract Computational tools are emerging as design tools for the development of total joint replacement with improved wear performance. The current wear models of polyethylene assume that wear is linearly proportional to sliding distance; however, it is hypothesized that the wear rate varies and is higher near a change in direction, but diminishes ...
Dressler, Matthew R., Strickland, Michael A., Taylor, Mark, Render, Todd D., Ernsberger, Craig N.   +4 more
openaire   +3 more sources

Augmentation of the mechanical and chemical resistance characteristics of an Al2O3-based refractory by means of high power diode laser surface treatment [PDF]

, 2003
Augmentation of the wear rate and wear life characteristics of an Al2O3-based refractory within both normal and corrosive (NaOH and HNO3) environmental conditions was effected by means of high power diode laser (HPDL) surface treatment.
Borodina, Bradley, Bradley, Bradley, Capelli, Dellaire, J Lawrence, Kobylanska-Szkaradek, L Li, Lawrence, Lawrence, Lawrence, Lawrence, Lawrence, Petitbon, Pou, Schmidt, Weitoa, Wu, Yang   +19 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Experimental Characterization of Electrical Discharge Machining of Aluminum 6061 T6 Alloy using Different Dielectrics [PDF]

, 2019
Electrical discharge machining is a non-traditional machining method broadly employed in industries for machining of parts that have typical profiles and require great accuracy.
Ismail, S. O., Khalid, Q. S., Niamat, M., Sarfraz, S., Shehab, E.   +4 more
core   +4 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Effect of flake graphite content on wear between behavior between P/M copper-based pantograph slide and contact wire

Materials Research Express, 2020
In this work, chromium-containing copper matrix com0posites with different flake graphite content (1.8 wt%, 2 wt%, 2.5 wt%) were fabricated by inexpensive powder metallurgy method, and the mechanical properties, friction properties and microstructure of ...
Jianxiang Huang, Man Wang, Yaochuan Li, Enze Xu, Ke Jiang, Meng Li, Honghai Zhong, Junwu Liu, Yang Jiang   +8 more
doaj   +1 more source

A comparison of the tribological behaviour of Y-TZP in tea and coffee under micro-abrasion conditions [PDF]

, 2013
The micro-abrasion of Y-TZP, a candidate dental restorative material, was investigated in a range of caffeine-containing solutions which included tea and coffee.
Sharifi, Shayan, Stack, Margaret
core   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source