Results 61 to 70 of about 20,228 (257)

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

Cognitive Outcome After Deep Brain Stimulation for Refractory Obsessive–Compulsive Disorder: A Systematic Review

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Introduction Deep brain stimulation (DBS) is an effective treatment for refractory obsessive–compulsive disorder (OCD). Neuropsychological assessment contributes to DBS treatment in several ways: it monitors the cognitive safety of the treatment, identifies beneficial or detrimental cognitive side effects and it could aid to explain ...
Tim A. M. Bouwens van der Vlis, Annelien Duits, Mégan M. G. H. van de Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens   +7 more
wiley   +1 more source

High incidence of Y‐chromosome mosaicism in male and female individuals with mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy

Epilepsia, EarlyView.
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an underrecognized pediatric cortical lesion associated with somatic X‐linked SLC35A2 variants in approximately 50% of individuals. The genetic etiology in individuals without detectable SLC35A2 mutations remains undefined, which limits
Erica Cecchini, Till Hartlieb, Ahmed Gaballa, Katja Kobow, Mitali Katoch, Paraskevi Chasani, Georgia Vasileiou, Wiebke Hofer, Lea M. Reisch, Manfred Kudernatsch, Christian G. Bien, Roland Coras, Ingmar Blümcke, Lucas Hoffmann   +13 more
wiley   +1 more source

Beyond seizures: A multidimensional approach to non‐seizure issues in Lennox–Gastaut syndrome. Insights from Italian experts

Epilepsia Open, EarlyView.
Abstract Non‐seizure issues (NSIs), including cognition, behavior/psychiatric symptoms, adaptive and social functioning, sleep, autonomic, and motor impairments, often shape day‐to‐day outcomes in Lennox–Gastaut syndrome (LGS) more than seizures, yet clinicians lack LGS‐specific, feasible assessment pathways.
Giancarlo Di Gennaro, Domenica Immacolata Battaglia, Paolo Bonanni, Gian Marco Duma, Antonietta Coppola, Edoardo Ferlazzo, Dario Pruna, Carlo Di Bonaventura   +7 more
wiley   +1 more source

Characteristics and long‐term outcomes of children with confirmed focal cortical dysplasia type 1 after epilepsy surgery: A population‐based study

Epilepsia Open, EarlyView.
Abstract Objective Focal cortical dysplasia type 1 (FCD1) is a rare and heterogeneous cause of drug‐resistant epilepsy (DRE) in children. Its clinical characteristics remain poorly understood, and surgical outcomes may be less favorable than in FCD2. We conducted a population‐based study to characterize the clinical presentation and long‐term seizure ...
Vincent Zheng, Päivi Koroknay‐Pál, Henri Lehtinen, Eija Gaily, Atte Karppinen, Anders Paetau, Olli Tynninen, Heta Leinonen, Aki Laakso, Eeva‐Liisa Metsähonkala   +9 more
wiley   +1 more source

REFLEXÕES TEÓRICAS E PRÁTICAS SOBRE A INTERPRETAÇÃO DA ESCALA DE INTELIGÊNCIA WECHSLER PARA ADULTOS [PDF]

Acta Colombiana de Psicología, 2012
The use of the Wechsler Intelligence Scales has entered clinical, psycho-educational and research settings, thus enabling a full assessment of cognitive abilities of children, adolescents and adults.
Fernandes Lopes, Regina Maria, Welter Wendt, Guilherme, Lima Argimon, Irani I. de, Rathke, Scheila Michele, Alves Senden, Débora, Ferreira Da Silva, Roselaine B.   +5 more
doaj  

Factors associated with better emotional, behavioural and educational outcomes in children with mild intellectual difficulties

JCPP Advances, EarlyView.
Abstract Background Children with mild intellectual difficulties (MID) are at increased risk of poor mental health and functional outcomes compared to typically developing children. Previous research has primarily focused on deficit‐based comparisons. However, substantial heterogeneity exists in this population, ranging from significant impairment to ...
Foteini Tseliou, Charlotte A. Dennison, Christopher B. Eaton, Jessica M. Armitage, Frances Rice, Stephan Collishaw   +5 more
wiley   +1 more source

Prenatal exposure to antihypertensive medication: A systematic review of neurodevelopmental and educational outcomes

JCPP Advances, EarlyView.
This systematic review investigated the association of prenatal exposure to antihypertensive medication with longer‐term poor neurodevelopmental outcomes by evaluating the findings from existing literature. We undertook a systematic review of previous studies looking specifically at neurodevelopmental outcomes in children.
Shrifah Alkhalaf, Sarjit Singh, Jill P. Pell, Scott M. Nelson, Daniel F. Mackay, Michael Fleming   +5 more
wiley   +1 more source

The Wechsler intelligence scale for children, fourth and fifth editions perform comparably in children with Batten disease

Orphanet Journal of Rare Diseases
Background The neuronal ceroid lipofuscinoses (Batten disease) are rare neurodegenerative lysosomal storage diseases principally of childhood onset and an autosomal recessive inheritance pattern. Cognitive regression is a hallmark of the disease, and has
Heather R. Adams, Erika F. Augustine, Kristen Bonifacio, Alyssa Collins, Amy E. Vierhile, Jonathan W. Mink   +5 more
doaj   +1 more source

Cognitive Profile Discrepancy as a Possible Predictor of Emotion Dysregulation in a Clinical Sample of Female Adolescents with Suicidal Behavior

European Journal of Investigation in Health, Psychology and Education
Emotional dysregulation (ED) has not yet been defined as a clinical entity, although it plays an important role in child and adolescent psychopathology.
Flora Furente, Federica Annecchini, Emilia Matera, Sabrina Serafino, Giorgia Frigeri, Alessandra Gabellone, Lucia Margari, Maria Giuseppina Petruzzelli   +7 more
doaj   +1 more source