Results 151 to 160 of about 13,336 (197)
Multiple Regulatory Mechanisms of Post-Translational Modifications and Therapeutic Potential of Mitotic Catastrophe. [PDF]
Int J Mol SciZhang QY +8 more
europepmc +1 more source
WEE1 Inhibitor: Clinical Development [PDF]
Current Oncology Reports, 2021 Abstract Purpose of Review WEE1 inhibitor has been shown to potential chemotherapy or radiotherapy sensitivity in preclinical models, particularly in p53-mutated or deficient cancer cells although not exclusively. Here, we review the clinical development of WEE1 inhibitor in combination with chemotherapy or radiotherapy ...
Anthony Kong, Hishām Mehanna
exaly +6 more sources
Cellular Signalling, 2022 Upon DNA damage, complex transduction cascades are unleashed to locate, recognise and repair affected lesions. The process triggers a pause in the cell cycle until the damage is resolved. Even under physiologic conditions, this deliberate interruption of cell division is essential to ensure orderly DNA replication and chromosomal segregation.
Siang-Boon Koh
exaly +5 more sources
Targeting WEE1 Kinase in Gynecological Malignancies [PDF]
Drug Design, Development and TherapyWEE1 kinase is involved in the G2/M cell cycle checkpoint control and DNA damage repair. A functional G2/M checkpoint is crucial for DNA repair in cancer cells with p53 mutations since they lack a functional G1/S checkpoint. Targeted inhibition of WEE1 kinase may cause tumor cell apoptosis, primarily, in the p53-deficient tumor, via bypassing the G2/M ...
Zhang,Wenhao, Li,Qingli, Yin,Rutie
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Development and Characterization of a Wee1 Kinase Degrader [PDF]
Cell Chemical Biology, 2020 The G1/S cell cycle checkpoint is frequently dysregulated in cancer, leaving cancer cells reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Wee1 regulates the G2/M checkpoint by phosphorylating CDK1 at Tyr15 to prevent mitotic entry.
Nathanael Gray +2 more
exaly +4 more sources
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Targeting WEE1 Kinase in Cancer
Trends in Pharmacological Sciences, 2016WEE1 kinase plays a crucial role in the G2-M cell-cycle checkpoint arrest for DNA repair before mitotic entry. Normal cells repair damaged DNA during G1 arrest; however, cancer cells often have a deficient G1-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is expressed at high levels in various cancer types including breast
Donald Backos +2 more
exaly +3 more sources
SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 inhibition
Nature Chemical Biology, 2023The cell-cycle checkpoint kinase WEE1 is emerging as a therapeutic target for cancer treatment. However, how its catalytic activity is regulated remains poorly understood, and reliable biomarkers for predicting response to WEE1 inhibitor remain to be identified.
Xiaomei Zhu +10 more
openaire +2 more sources
Science Signaling, 2009
Pom1 gradients coordinate cell division with cell size.
openaire +1 more source
Pom1 gradients coordinate cell division with cell size.
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WEE1 Kinase As a Target for Cancer Therapy
Journal of Clinical Oncology, 2015Exploiting the complex machinery that regulates cell cycle checkpointsandDNArepair forcancertherapyhasbeenthefocusofmanypast and ongoing investigations; however, successful translation into patient care and meaningful impact on clinical outcomes have proven elusive. Eukaryotic cells rely on complex cell cycle checkpoint and DNA repair systems to ensure
Sabine, Mueller, Daphne A, Haas-Kogan
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A WEE1 homologue from Arabidopsis thaliana
Planta, 2002Little is known about the genes that regulate cyclinB-Cdc2 complexes at the G2/M transition of the plant cell cycle although in yeast and animals cdc25 and wee1 are central regulators of cdc2. Here we describe the isolation, by reverse transcription polymerase chain reaction (RT-PCR), of a WEE1 cDNA (AtWEE1) in Arabidopsis thaliana (L.) Heynh.
David A, Sorrell +5 more
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