Results 161 to 170 of about 13,336 (197)

Targeting WEE1 Kinase for Breast Cancer Therapeutics: An Update

International Journal of Molecular Sciences
WEE1 kinase is a crucial cell cycle regulatory protein that controls the timing of mitotic entry. WEE1, via inhibition of Cyclin-dependent Kinase 1 (CDK1) and Cyclin-dependent Kinase 2 (CDK2), governs the G2-M checkpoint by inhibiting entry into mitosis.
Anthony Ashton, Richard Pestell
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Wee1+-like gene in human cells

Nature, 1991
The wee1+ gene is a mitotic inhibitor controlling the G2 to M transition of the fission yeast Schizosaccharomyces pombe and encodes a protein kinase with both serine- and tyrosine-phosphorylating activities. We have cloned a human gene (WEE1Hu) similar to wee1+ by transcomplementation of a yeast mutant.
M, Igarashi, A, Nagata, S, Jinno, K, Suto, H, Okayama   +4 more
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WEE1 inhibition and genomic instability in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2013
One of the hallmarks of cancer is genomic instability controlled by cell cycle checkpoints. The G1 and G2 checkpoints allow DNA damage responses, whereas the mitotic checkpoint enables correct seggregation of the sister chromosomes to prevent aneuploidy. Cancer cells often lack a functional G1 arrest and rely on G2 arrest for DNA damage responses. WEE1
Vriend, L.E.M., Versélewel de Witt Hamer, P.C., van Noorden, C.J.F., Wurdinger, T.   +3 more
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Investigation of biaryl heterocycles as inhibitors of Wee1 kinase

Bioorganic & Medicinal Chemistry Letters, 2019
In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were designed, synthesized and evaluated. The new biaryl cores were designed to enable structure-activity exploration of substituents at C-8 or N-8 which were used for tuning compound properties and to
Anthony, Mastracchio, Chunqiu, Lai, Maricel, Torrent, Kenneth, Bromberg, Fritz G, Buchanan, Debra, Ferguson, Velitchka, Bontcheva, Eric F, Johnson, Loren, Lasko, David, Maag, Alexander R, Shoemaker, Thomas D, Penning   +11 more
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Targeting WEE1 in Pancreatic Cancer

Cancer Discovery, 2019
Abstract According to results from a phase I/II trial, the investigational WEE1 inhibitor adavosertib combined with gemcitabine and radiation is well tolerated and may benefit patients with locally advanced pancreatic adenocarcinoma by increasing both systemic and local disease control.
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[WEE1, histone and tumor].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2015
WEE1 is an important factor for histone transcription, chromosome condensation and regulation of cell cycle progression. WEE1 kinase can phosphorylate Cdc2 and down-regulate Cdc2 kinase activity. It can regulate G2 to M phase transition and cell mitosis.
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Wee1

AfCS-Nature Molecule Pages, 2008
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Wee1

1995
Hiroto Okayama, Makato Igarashi, Akihisa Nagata   +2 more
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WEE1 inhibition after platinum resistance

Nature Reviews Clinical Oncology, 2021
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Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy

International Journal of Molecular Sciences, 2021
Stefano Forte, Raffaella Giuffrida, Francesca Esposito   +2 more
exaly