Results 121 to 130 of about 499,052 (176)

Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers. [PDF]

NPJ Precis Oncol
Kim D, Chung H, Liu W, Jeong K, Ozmen TY, Ozmen F, Rames MJ, Kim S, Guo X, Jameson N, de Jong PR, Yea S, Harford L, Li J, Mathews CA, Doroshow DB, Charles VJ, Kim D, Fischer K, Samatar AA, Jubb A, Bunker KD, Blackwell K, Simpkins F, Meric-Bernstam F, Mills GB, Harismendy O, Ma J, Lackner MR.   +28 more
europepmc   +1 more source

Regulation of neuronal CDC2 like kinase by wee1 like kinase

Pathophysiology, 1994
M. Matsushita, I. Matsuura, K. Tomizawa, T. Itano, H. Matsui, M. Tokuda, H. Suwaki, O. Hatase, Jerry H. Wang   +8 more
openaire   +1 more source

Anti-Tumor Effects of Wee1 Kinase Inhibitor with Radiotherapy in Human Cervical Cancer. [PDF]

Sci Rep, 2019
Lee YY, Cho YJ, Shin SW, Choi C, Ryu JY, Jeon HK, Choi JJ, Hwang JR, Choi CH, Kim TJ, Kim BG, Bae DS, Park W, Lee JW.   +13 more
europepmc   +1 more source

Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition. [PDF]

Mol Cancer Res, 2019
Diab A, Kao M, Kehrli K, Kim HY, Sidorova J, Mendez E.   +5 more
europepmc   +1 more source

WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells. [PDF]

Proc Natl Acad Sci U S A, 2019
Moiseeva TN, Qian C, Sugitani N, Osmanbeyoglu HU, Bakkenist CJ.   +4 more
europepmc   +1 more source

Cyclin E Overexpression Sensitizes Triple-Negative Breast Cancer to Wee1 Kinase Inhibition. [PDF]

Clin Cancer Res, 2018
Chen X, Low KH, Alexander A, Jiang Y, Karakas C, Hess KR, Carey JPW, Bui TN, Vijayaraghavan S, Evans KW, Yi M, Ellis DC, Cheung KL, Ellis IO, Fu S, Meric-Bernstam F, Hunt KK, Keyomarsi K.   +17 more
europepmc   +1 more source

Characterisation of WEE1 regulation at mitosis

Wee1 is a tyrosine kinase that plays a major role in regulating mitotic entry. Throughout G2 phase, it phosphorylates and inhibits Cdk1, the master mitotic regulator, thereby preventing mitotic entry.
Johnson, V
core  

On the road to destruction: coupling cyclin B degradation to proteolysis independent MPF inactivation [PDF]

, 2007
D'Angiolella, Vincenzo
core   +1 more source

Combined Inhibition of Wee1 and Checkpoint Kinases Synergistically Provokes S-Phase Progression and Mitotic Entry, and Promotes Cell Death Under Heat Stress. [PDF]

Genes Cells
Muratani T, Takeya H, Ishibashi R, Kurakawa T, Ikushiro SI, Nagai Y, Tabuchi Y, Kondo T, Furusawa Y.   +8 more
europepmc   +1 more source

WEE1 Inhibition as a Novel Therapeutic Strategy in Cutaneous T-Cell Lymphoma. [PDF]

Cancers (Basel)
Özistanbullu D, Bahrami K, Doll M, Reichenbach G, Pöschl SM, Wilhelm R, Stege H, Zöller N, Winkler L, Jäger M, Nicolay JP, Quist SR, Kaufmann R, Meissner M, Schilling B, Kleemann J, Cinatl J, Kippenberger S.   +17 more
europepmc   +1 more source