Results 161 to 170 of about 6,786,852 (260)

Safety, Tolerability, Pharmacokinetics and Exploratory Pharmacodynamics of Melanin‐Concentrating Hormone Receptor‐1 Antagonist RGH‐706 in Healthy and Overweight or Obese Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim This Phase 1 program evaluated the safety, tolerability, pharmacokinetics and exploratory pharmacodynamics of the novel melanin‐concentrating hormone receptor‐1 antagonist RGH‐706. Methods Study A was a first‐in‐man, randomized trial comprising a double‐blind, placebo‐controlled single‐ascending‐dose part (0.1–162.5 mg) and a two‐way ...
Thomas Brevig, Borbála Szepes, Zsófia Borbála Dombi, Gabriella Magyar, Zoltán Juhász, Margit Kapás, Éva Cseh, Zsuzsa Hegedűs, Tibor Farkas, Zsuzsanna Kiss, Balázs Szatmári   +10 more
wiley   +1 more source

Efficacy and Feasibility of Just‐in‐Time Nudging in Reducing Evening Snacking Measured by Continuous Glucose Monitoring in Adults With Type 2 Diabetes: A Micro‐Randomized Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study aimed to determine whether in people with Type 2 diabetes mellitus (T2DM), a digital nudge delivered by a smartphone app soon after dinner reduces subsequent snacking events as measured by continuous glucose monitoring (CGM). Methods Participants: Adults with T2DM, managed with diet or stable oral antidiabetic medication for at
Lijun Zhao, Niranjan Bidargaddi, Andrew Vakulin, Wenhao Li, Natalie Luscombe‐Marsh, Fiona Benton, Robert Adams, Eva Kemps, Andrew D. Vincent, Leonie K. Heilbronn, Gary A. Wittert   +10 more
wiley   +1 more source

Anthropometric, Muscle Function, Physical Activity, Inflammatory and Dietary Characteristics Associated With Fasting Glucose and Insulin Resistance in Rural and Urban Malawian Adults: A Cross‐Sectional Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims In African populations, Type 2 diabetes often occurs at relatively low BMI. We examined anthropometric, muscle function, physical activity, inflammatory and dietary correlates of fasting glucose and insulin resistance. Materials and Methods Nutrition and Metabolic Health in Malawi (NUTRI‐MET Malawi) recruited 100 adults from rural Karonga
Shekinah Munthali‐Mkandawire, McDonald Chabwera, Louis Banda, Christine A. Edwards, Cindy M. Gray, Stuart R. Gray, Naveed Sattar, Christopher Bunn, Amelia C. Crampin, Jason M. R. Gill   +9 more
wiley   +1 more source

Efficacy and Safety of CagriSema in Type 2 Diabetes: A Dose‐ and Comparator‐Specific Systematic Review and Bayesian Meta‐Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background CagriSema combines cagrilintide with semaglutide and may improve glycaemic control and body weight in Type 2 diabetes. We evaluated its dose‐ and comparator‐specific efficacy and safety. Methods PubMed, Embase, CENTRAL and ClinicalTrials.gov were searched through 30 June 2026 for randomized controlled trials.
Chia Siang Kow, Abdullah Faiz Zaihan, Dinesh Sangarran Ramachandram, Kaeshaelya Thiruchelvam   +3 more
wiley   +1 more source

Waist Circumference as the Newest Vital Sign: An Evaluation of Abdominal Obesity in the Healthcare Setting

DNP projectIntroduction/Purpose: Body mass index (BMI), which is based on the height and weight of an individual, has traditionally been the sole screening tool to identify obesity in the clinical setting.
Hawkins, Ericka A.
core  

Daytime Sleepiness, Insomnia Symptoms and Sleep Quality in Adults Entering a Structured Weight‐Loss Programme: The SCOOP‐RNPC Cohort

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Daytime sleepiness, insomnia and poor sleep quality are common in adults with overweight/obesity. This study characterized these sleep‐related complaints and their associations with clinical characteristics at entry into the Nutritional and Psycho‐Behavioural Rehabilitation (RNPC) programme, identified clinical characteristics ...
Odile Fabre, Sébastien Bailly, Ophélie Coiffier, Laurent Pantagis, Rémy Legrand, Jean‐Louis Pépin   +5 more
wiley   +1 more source

The natural history of periodontal disease—Part 2: In populations with access to dental care: The Studies of Health in Pomerania (SHIP)

Periodontology 2000, EarlyView., 2023
Abstract In this descriptive analysis of the 21‐year follow‐up data from the SHIP‐START cohort and the 7‐year follow‐up data from the SHIP‐TREND cohort, we report the progression of clinical attachment levels (CAL), age effects on CAL change, and a detailed description of CAL progression and remission. At baseline, 4307 and 4420 persons participated in
Thomas Kocher, Peter Meisel, Reiner Biffar, Henry Völzke, Birte Holtfreter   +4 more
wiley   +1 more source

Association of Weight-Adjusted Waist Index with All-Cause and Cardiovascular Mortality in Patients with Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study [PDF]

Xiaoning Zhang,* Wenqing Zhang,* Yajie Hu, Guang Yang, Shuangteng Liu, Wenqiang Hao, Yiqing Qu Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China*These ...
Zhang W, Yang G, Hu Y, Zhang X, Hao W, Liu S, Qu Y   +6 more
core  

Differential Cardiometabolic Risk Profiles of Lean and Obese Metabolic Dysfunction–Associated Steatotic Liver Disease: A Longitudinal Health Checkup Cohort Study

Hepatology Research, EarlyView.
Lean and Obese MASLD shared a common cardiometabolic basis, but the relative contributions of individual risk factors differed between phenotypes. Longitudinal changes in triglycerides and ALT were associated with incident MASLD in both phenotypes, reflecting evolving metabolic–hepatic vulnerability.
Hayato Kawamura, Kei Fujiwara, Ryo Sato, Takanori Suzuki, Kiyoto Narita, Kentaro Matsuura, Shunsuke Nojiri, Shigehiro Shiraki, Hiromi Kataoka   +8 more
wiley   +1 more source

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

Periodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti, Jean E. Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source