Results 81 to 90 of about 1,296,830 (230)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Identification of indicators used to assess needs for telemedicine consultations in various profiles of medical care [PDF]

Digital Diagnostics
BACKGROUND: A unified system for assessing the results and real contributions of telemedicine consultations to improving medical care quality in the healthcare system of the Russian Federation has not yet been developed.
Elena S. Samsonova, Ilya A. Mikhailov, Vitaly V. Omelyanovsky, Maria V. Avksentieva, Inna A. Zheleznyakova, Georgy G. Lebedenko   +5 more
doaj   +1 more source

An aerodynamic load criterion for airships [PDF]

, 1975
A simple aerodynamic bending moment envelope is derived for conventionally shaped airships. This criterion is intended to be used, much like the Naval Architect's standard wave, for preliminary estimates of longitudinal strength requirements.
Woodward, D. E.
core   +1 more source

Deterministic weighted scale-free small-world networks

, 2010
We propose a deterministic weighted scale-free small-world model for considering pseudofractal web with the coevolution of topology and weight. In the model, we have the degree distribution exponent $\gamma$ restricted to a range between 2 and 3 ...
Andrade, Andrade, Andrade, Barabási, Barrat, Barrat, Barrat, Bollt, Comellas, Dorogovtsev, Dorogvtsev, Hinczewski, Iguchi, Jihong Guan, Jung, Karsai, Kujawski, Kwon, Leland, Lind, Maslov, Meloni, Nacher, Newman, Newman, Newman, Noh, Pastor-Satorras, Ravasz, Ravasz, Shuigeng Zhou, Song, Vázquez, Vázquez, Wang, Wang, Wu, Xie, Xu, Yan, Yang, Yichao Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhongzhi Zhang, Zhou, Zhou, Zhou, Zhou   +51 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The age and growth of the tongue sole Cynoglossus canariensis (Steind 1882) [PDF]

, 1983
The geometric mean regression equation for the weight; length relationship of Cynoglossus canariensis was W = 0.0025 L super(3.1770). The Von Bertalanffy constants Woo, Loo, K, and to were 507.5852 g, 47.3683 cm, 0.3333 and 0.1397 for males and 839.0753 ...
Ajayi, T.O.
core  

Rethinking Attention Weights as Bidirectional Coefficients

Journal of Data Science
Attention mechanism has become an almost ubiquitous model architecture in deep learning. One of its distinctive features is to compute non-negative probabilistic distribution to re-weight input representations. This work reconsiders attention weights as bidirectional coefficients instead of probabilistic measures for potential benefits in ...
Yuxiang Huang, Hanfang Yang, Xingrui Wang   +2 more
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source