Results 61 to 70 of about 667,397 (267)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
On a New Extended Hardy–Hilbert’s Inequality with Parameters
Mathematics, 2020 In this paper, by introducing parameters and weight functions, with the help of the Euler−Maclaurin summation formula, we establish the extension of Hardy−Hilbert’s inequality and its equivalent forms.
Bicheng Yang, Shanhe Wu, Jianquan Liao
doaj +1 more source
Coefficients of half-integral weight modular forms
Journal of Number Theory, 2003 Inspired by Kolyvagin's celebrated work on the Birch and Swinnerton-Dyer Conjecture and works of Waldspurger, Kohnen and Zagier relating the Fourier coefficients of half-integral weight Hecke eigenforms to values of modular \(L\)-functions (there have been a number of works on the indivisibility of the coefficients of half-integral weight modular forms)
Bruinier, Jan H., Ono, Ken
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
An extension of a multidimensional Hilbert-type inequality
Journal of Inequalities and Applications, 2017 In this paper, by the use of weight coefficients, the transfer formula and the technique of real analysis, a new multidimensional Hilbert-type inequality with multi-parameters and a best possible constant factor is given, which is an extension of some ...
Jianhua Zhong, Bicheng Yang
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Identification of indicators used to assess needs for telemedicine consultations in various profiles of medical care [PDF]
Digital DiagnosticsBACKGROUND: A unified system for assessing the results and real contributions of telemedicine consultations to improving medical care quality in the healthcare system of the Russian Federation has not yet been developed.
Elena S. Samsonova +5 more
doaj +1 more source
Standardization of Weighted Ranking Correlation Coefficients
CoRR24 pages, 5 ...
openaire +2 more sources