Results 81 to 90 of about 667,397 (267)
The Mechanism of Lavender Essential Oil in the Treatment of Acute Colitis Based on "Quantity-Effect" Weight Coefficient Network Pharmacology. [PDF]
Front Pharmacol, 2021 Wang Y +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Tongxin xuebao, 2014 To investigate the invulnerability of small-world networks against cascading failure, an improved nonlinear load-capacity model was introduced. Under the rule of local weighted load redistribution, the influence of weight coeffi-cient, capacity ...
Xiao-ping WU +3 more
doaj
A relation between two simple Hardy-Mulholland-type inequalities with parameters
Journal of Inequalities and Applications, 2016 By means of weight coefficients and the technique of real analysis, a new Hardy-Mulholland-type inequality with the kernel K λ ( m , n ) : = 1 ln λ U m + ln λ V n + α | ln λ U m − ln λ V n | $$ K_{\lambda}(m,n):=\frac{1}{\ln^{\lambda}U_{m}+\ln^{\lambda ...
Qiang Chen, Yanping Shi, Bicheng Yang
doaj +1 more source
Reflection Coefficients for the Generalized Jacobi Weight Functions
Journal of Approximation Theory, 1994 Let \(w(t)= f(t) \prod^ N_ 1 | e^{it}- e^{it_ j}|^{\gamma_ j}\) be a generalized Jacobi weight on the unit circle, where \(\gamma_ j> -1\) and \(h\) is a smooth differentiable function. Consider the orthonormal polynomials \(\{\Phi_ n\}\) associated with \(w\) and the so-called reflection coefficients \(\Phi_ n(0)\) for them.
openaire +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source