Results 71 to 80 of about 667,397 (267)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

International and Russian practice of banking risk-management. Mortgage risks

Статистика и экономика, 2016
The goal of the work is to compare Russian norms and standards of risk management of mortgage lending with international standards of risk management based on the documents of the Basel Committee.
A. V. Nikolaeva
doaj   +1 more source

On recurrence coefficients for rapidly decreasing exponential weights

Journal of Approximation Theory, 2007
The main problem under consideration in the present paper is the relationship between the rate of convergence of the recurrence coefficients, and the rate of decay of the exponential weight at the endpoints of the orthogonality interval \((a,b)\) (finite or infinite).
Eli Levin, Doron S. Lubinsky
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

An Investigation on CCT and Ra Optimization for Trichromatic White LEDs Using a Dual-Weight-Coefficient-Based Algorithm. [PDF]

Micromachines (Basel), 2022
Xiao H, Li Y, Li B, Wang G.
europepmc   +1 more source

A three‐vector model predicting torque control of permanent magnet synchronous motor with a fixed weight coefficient

IET Cyber-Physical Systems
The difficulty of adjusting the weighting coefficients of the cost function in traditional model predictive torque control is addressed by proposing a fixed weighting coefficient three‐vector model predictive torque control (FWC‐MPTC) strategy.
Xingyu Qu, Chengkun Peng, Peng Lu, Bing Ge, Shuang Zhang, Qinghe Wang, Zhenyang Li   +6 more
doaj   +1 more source

Energy efficiency analysis of energy facilities using ranking methods

Известия высших учебных заведений: Проблемы энергетики
RELEVANCE. Increasing energy efficiency is one of the necessary conditions for modernizing the Russian economy. High energy intensity and energy efficiency analysis are due to the combined influence of a number of factors, both global and private.
V. M. Less, V. Y. Lyubchenko, D. A. Pavlyuchenko   +2 more
doaj   +1 more source

Quadratically Weighted Agreement Coefficients: Interpretations and Connections

Psychometrika
Abstract In this study, we review interpretations and connections of chance-corrected agreement coefficients with quadratic weights, applicable when raters classify objects or subjects on an ordinal scale. Whereas correlation interpretations exist for coefficients with noninterchangeable raters, represented by Cohen’s two-rater and ...
Rutger, van Oest, Jonas, Moss
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source