Results 181 to 190 of about 719,182 (313)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Factors associated with perceived weight gain among the adult population of Kazakhstan during the COVID-19 pandemic. [PDF]

PLoS One
Bukharbayeva A, Davis A, Rosenthal SL, Myrkassymova A, Iskakova B, Izekenova A, Izekenova A, Yerdenova M, Karibayev K, Zhussupov B, Mergenova G.   +10 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Evaluation of Weight Gain and Overall Survival of Men Versus Women With Advanced Non-Small Cell Lung Cancer. [PDF]

J Cachexia Sarcopenia Muscle
Roeland EJ, Fintelmann FJ, Yang R, Tarasenko L, Bonomi PD.   +4 more
europepmc   +1 more source

Effects of maternal body mass index and weight gain during pregnancy on the outcome of delivery

, 2007
A Tabandeh, Ehsan Kashani
openalex   +1 more source

Impact of Second Trimester Maternal Dietary Intake on Gestational Weight Gain and Neonatal Birth Weight [PDF]

, 2017
Malshani Lakshika Pathirathna, Kayoko Sekijima, Mieko Sadakata, Naoshi Fujiwara, Yoshiyuki Muramatsu, K. M. S. Wimalasiri   +5 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Gestational weight gain and estimated fetal growth in different trimesters among Saudi women. [PDF]

Pak J Med Sci
Nazir II.
europepmc   +1 more source

Association between gestational weight gain and pregnancy outcomes, neonatal birth weight, and maternal postpartum glucose tolerance in Japanese gestational diabetes mellitus patients: comparison of old and new gestational weight gain standards

Akiho Yamashita, Masayuki Kaku, Tadamitsu Ideguchi, Shuhei Nishida, Hiroyuki Kinoshita, Takeshi Nishikawa   +5 more
openalex   +2 more sources