Results 181 to 190 of about 2,675,508 (307)

The effects of antenatal interventions on gestational weight gain in low and middle-income countries: a systematic review. [PDF]

BMJ Glob Health
Aggrey PA, Nguyen CH, Asghari-Kamrani A, Fawzi WW, Wang D.   +4 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis-Application in a Real-World Setting. [PDF]

Hum Psychopharmacol
Heald A, Illangasekera Y, Loureiro CM, Shakespeare M, Jameson A, Phillipson A, Reynolds GP, Dalton C.   +7 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Maternal History of Weight Loss and Prospective Gestational Weight Gain.

JAMA Netw Open
Muse ME, Gilbert-Diamond D, Madan J, Peacock JL, Karagas MR, Howe CG.   +5 more
europepmc   +1 more source

The effect of gestational weight gain on the infant gut microbiome- a systematic review of the literature. [PDF]

Front Cell Infect Microbiol
Xixi NA, Karamanolis G, Vlachogianni EE, Voulgaris T, Sokou R, Volaki P, Paliatsiou S, Iliodromiti Z, Iacovidou N, Boutsikou T.   +9 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Cafeteria diet exposure, and not weight gain propensity, impacts gut microbiota of rats - a within laboratory meta-analysis. [PDF]

Gut Microbes Rep
Bhagavata Srinivasan SP, Kendig MD, Hasebe K, Kaakoush NO, Morris MJ, Leigh SJ.   +5 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Recommendations for energy intake and weight gain for pregnant women with obesity. [PDF]

Chin Med J (Engl)
Juan J, Zhang X, Wang X, Gao D, Shu X, Kang X, Xue Y, Wang X, Chen Y, Yang H.   +9 more
europepmc   +1 more source