Results 251 to 260 of about 2,032,974 (307)
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
wiley +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley +1 more source
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Perceptual Accuracy in the Balance: The Weight of the Evidence and the Evidence of Weight
Journal of Social and Personal Relationships, 1998In two studies, we investigated whether individuals were accurate in perceiving weight-related attitudes of their romantic partner. We also investigated whether accuracy was moderated by whether the partner was currently attempting to lose weight, relationship commitment level, amount of discussion about weight and importance of weight. Each individual
Eddie M. Clark +4 more
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JAMA: The Journal of the American Medical Association, 1970
My lords, the happenings of this case are, to wit: Robert the Surgeon, of Friday Street, rented a house and tavern to one Symon, in St. Martin's parish, there to conduct his trade. Said Symon had a servant, Roger from Westminster, who, in the night following St.
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My lords, the happenings of this case are, to wit: Robert the Surgeon, of Friday Street, rented a house and tavern to one Symon, in St. Martin's parish, there to conduct his trade. Said Symon had a servant, Roger from Westminster, who, in the night following St.
openaire +2 more sources
Archives of Pediatrics & Adolescent Medicine, 1954
PART OF the clinician's job is to gather evidence; another part is to interpret it. Practically all of us are teachers of pediatrics, at least in the bonds of the Hippocratic oath if not actually on a university payroll. As such we have the dual responsibility of evaluating clinical evidence in the course of our own work with patients and of teaching ...
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PART OF the clinician's job is to gather evidence; another part is to interpret it. Practically all of us are teachers of pediatrics, at least in the bonds of the Hippocratic oath if not actually on a university payroll. As such we have the dual responsibility of evaluating clinical evidence in the course of our own work with patients and of teaching ...
openaire +2 more sources
Episteme, 2008
ABSTRACTInterest in the Keynesian concept of evidential weight has led to divergent views concerning the burden of proof in adjudication. It is argued that Keynes's concept is properly engaged only in the context of one special kind of decision, the decision whether or not the evidence is ripe for a decision on the underlying merits, whether the latter
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ABSTRACTInterest in the Keynesian concept of evidential weight has led to divergent views concerning the burden of proof in adjudication. It is argued that Keynes's concept is properly engaged only in the context of one special kind of decision, the decision whether or not the evidence is ripe for a decision on the underlying merits, whether the latter
openaire +1 more source
2021
Abstract This chapter analyzes and operationalizes a concept of “weight” as denoting the relative degree to which evidence has been developed on the basis of which to determine disputed claims. This concept was coined by John Maynard Keynes and later applied in the context of judicial proof by a number of scholars.
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Abstract This chapter analyzes and operationalizes a concept of “weight” as denoting the relative degree to which evidence has been developed on the basis of which to determine disputed claims. This concept was coined by John Maynard Keynes and later applied in the context of judicial proof by a number of scholars.
openaire +1 more source
2021
Courts of law must weigh evidence to determine the likelihood of competing interpretations of past events, and different legal contexts require different standards of proof, but this falls short of a quantification of probability. Bayes’s theorem and the associated formula provide a way of combining multiple elements of evidence and using them to ...
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Courts of law must weigh evidence to determine the likelihood of competing interpretations of past events, and different legal contexts require different standards of proof, but this falls short of a quantification of probability. Bayes’s theorem and the associated formula provide a way of combining multiple elements of evidence and using them to ...
openaire +1 more source