Results 71 to 80 of about 2,032,974 (307)

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

An abductive inferential system approach to weight of evidence syntheses: the problem and military exposures worked example

Evidence-Based Toxicology
Objective Weight of Evidence methods for evidence synthesis of etiological epidemiology questions regarding historical complex exposures have been developed in recent years but are still in their nascency.
J. Scott Parrott, Shobhik Chakraborty, Frederick Coffman, Albert Heuer, Jane Heetderks-Cox, Tami Piemonte, Chelsea Rodriguez, Jacquelyn Mares, Sarah Levan, Salvatore Butera, Marissa J. Coloske, Michael Falvo   +11 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

WoE Analysis and Key Risk Factors in Preclinical Development of Medicinal Products: A Review

Безопасность и риск фармакотерапии
INTRODUCTION. In recent years, the Russian Federation and the Eurasian Economic Union have included the concept of ‘weight of evidence’ (WoE) in regulatory documents.
G. N. Engalycheva, R. D. Syubaev
doaj   +1 more source

Testosterone and weight loss [PDF]

Current Opinion in Endocrinology, Diabetes & Obesity, 2014
The purpose of this article is to examine the contemporary data linking testosterone therapy in overweight and obese men with testosterone deficiency to increased lean body mass, decreased fat mass, improvement in overall body composition and sustained weight loss.
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

What Determines Post-Compulsory Educational Choice? Evidence from the Longitudinal Survey of Young People in England [PDF]

, 2011
Using a unique dataset which is rich in both family background and attainment in education, we find that educational attainments at the end of the compulsory schooling stage are powerful predictors for post-compulsory educational choices in England.
Collier, William J., Zhu, Yu, Valbuena, Javier, Collier, William   +3 more
core  

A study on forest fire risk assessment in jiangxi province based on machine learning and geostatistics

Environmental Research Communications
Jiangxi Province, characterized by abundant forest resources and complex topography, is highly susceptible to forest fires. This study integrated multiple factors, including topography, climate, vegetation, and human activities, and employed machine ...
Jinping Lu, Mangen Li, Yaozu Qin, Niannan Chen, Lili Wang, Wanzhen Yang, Yuke Song, Yisu Zheng   +7 more
doaj   +1 more source

An Explainable Hybrid AI Framework for Real-Time Point-of-Sale Credit Scoring

AI
Point-of-sale (POS) consumer credit represents the most rapidly expanding retail-lending channel within the emerging Eurasian markets, necessitating a stringent operational framework for the underwriting model: the decision must be rendered within a mere
Gulnaz Zakariya, Aiman Moldagulova, Nor’ashikin Ali   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source