Results 51 to 60 of about 745,851 (257)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Self-adaption image weighted mean filter design based on FPGA
Dianzi Jishu Yingyong, 2019 In order to solve the problem of noise preprocessing in the process of image acquisition by complementary metal oxide semiconductor(CMOS) image sensor, a configurable adaptive weighted mean filter module in FPGA is proposed.
Wu Haonan +3 more
doaj +1 more source
Algebraic representations of the weighted mean
Fuzzy Sets and Systems, 2017 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bortot, Silvia +1 more
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Some weighted operator geometric mean inequalities
پژوهشهای ریاضی, 2017 In this paper, using the extended Holder- -McCarthy inequality, several inequalities involving the α-weighted geometric mean ...
Alemeh Sheikhhosseini +2 more
doaj
Projected shrinking of tropical vegetation biomass potential with future hydroclimatic shifts
Environmental Research LettersGlobal change threatens the carbon stocks stored in tropical ecosystems. However, considerable uncertainty remains regarding the estimates of these future carbon losses.
Félicien Meunier +7 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
An Analysis of Winsorized Weighted Means [PDF]
Group Decision and Negotiation, 2019 Producción ...
openaire +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source