Results 101 to 110 of about 503,198 (296)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
GrAviPaSt’s Lens to the Past: Unveiling the Evolution of Filamentary Structures
The Astrophysical JournalThis paper examines the evolution of cosmic filaments across redshifts 1, 0.5, and 0 using the IllustrisTNG100-1 magnetohydrodynamical simulation. To achieve this, we introduce GrAviPaSt, a simple, efficient, and parameter-free filament identification ...
Parsa Ghafour, Saeed Tavasoli
doaj +1 more source
Tauberian theorems for the weighted mean method of summability of integrals
, 2020 Fırat Özsaraç, İbrahim Çanak
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Water Temperature Prediction Using Improved Deep Learning Methods through Reptile Search Algorithm and Weighted Mean of Vectors Optimizer [PDF]
, 2023 Rana Muhammad Adnan Ikram +5 more
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ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
MULTIPLE CRITERA METHODS WITH FOCUS ON ANALYTIC HIERARCHY PROCESS AND GROUP DECISION MAKING
Croatian Operational Research Review, 2010 Managing natural resources is a group multiple criteria decision making problem. In this paper the analytic hierarchy process is the chosen method for handling the natural resource problems. The one decision maker problem is discussed and, three methods:
Lidija Zadnik-Stirn, Petra Grošelj
doaj
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Multi-Objective Geometric Programming Problem Being Cost Coefficients as Continous Function with Weighted Mean Method [PDF]
, 2010 Akshay Kumar Ojha, Asim K. Das
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