Results 81 to 90 of about 1,675,186 (285)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Complexity, 2018 The aim of this paper is to develop partitioned Pythagorean fuzzy interaction Bonferroni mean operators based on the Pythagorean fuzzy set, Bonferroni mean, and interaction between membership and nonmembership.
Wei Yang +4 more
doaj +1 more source
Bandwidth Selection for Semiparametric Estimators Using the m-out-of-n Bootstrap [PDF]
This paper considers a class of semiparametric estimators that take the form of density-weighted averages. These arise naturally in a consideration of semiparametric methods for the estimation of index and sample-selection models involving preliminary ...
Chuan Goh
core
Multi-objective Geometric Programming Problem With Weighted Mean Method
, 2010 Pages IEEE format, International Journal of Computer Science and Information Security, IJCSIS February 2010, ISSN 1947 5500, http://sites.google.com/site/ijcsis/
Ojha, A. K., Biswal, K. K.
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A Test for the Zero Mean Hypothesis in Cosmology
, 2014 One working hypothesis on which analyses of cosmological data are based is the zero ensemble mean hypothesis, which is related to the statistical homogeneity of cosmological perturbations.
Ichiki, Kiyotomo
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Median as a weighted arithmetic mean of all sample observations [PDF]
This paper shows how median may be computed as a weighted arithmetic mean of all sample observations, unlike the conventional method that obtains median as the middle value (odd observations) or a simple mean of the two middlemost values (even ...
SK Mishra
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source