Results 51 to 60 of about 1,675,186 (285)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Determination of Ceres mass based on the most gravitationally efficient close encounters

, 2011
Here is presented recalculated value of the mass of Ceres, based on explicit tracking of its gravitational influence on orbits evolution of 21 selected asteroids during their mutual close encounters (CE).
Andjelka B. Kovačević, Baer, Bowell, Britt, Christou, Cox, Goffin, Goffin, Hilton, Hilton, Hilton, Hilton, Hoffmann, Ivezić, Kochetova, Kolmogorov, Konopliv, Kovačević, Kovačević, Kuzmanoski, Kuzmanoski, Michalak, Opik, Piotrwski, Pitjeva, Pitjeva, Press, Sitarski, Sitarski, Smirnov, Tedesco, Viateau, Viateau, Viateau, Williams   +34 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Cluster-Weighted Kernel K-Means Method for Multi-View Clustering

Proceedings of the AAAI Conference on Artificial Intelligence, 2020
Clustering by jointly exploiting information from multiple views can yield better performance than clustering on one single view. Some existing multi-view clustering methods aim at learning a weight for each view to determine its contribution to the final solution.
Jing Liu, Fuyuan Cao, Xiao-Zhi Gao, Liqin Yu, Jiye Liang   +4 more
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Least Square and the Weighted Least Square Methods for Estimating the Weibull Distribution Parameters - A Comparative Study

Communications, 2012
In this paper we study the performance of the least square method and the weighted least square method for estimating the Weibull distribution parameters. In engineering practice these methods are commonly used due to their simplicity.
Ivana Pobocikova, Zuzana Sedliackova
doaj   +1 more source

A New GNSS-R Altimetry Algorithm Based on Machine Learning Fusion Model and Feature Optimization to Improve the Precision of Sea Surface Height Retrieval

Frontiers in Earth Science, 2021
The global navigation satellite system reflectometer (GNSS-R) can improve the observation and inversion of mesoscale by increasing the spatial coverage of ocean surface observations.
Qiang Wang, Qiang Wang, Wei Zheng, Wei Zheng, Wei Zheng, Fan Wu, Aigong Xu, Huizhong Zhu, Zongqiang Liu, Zongqiang Liu   +9 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Prostate MR image segmentation using 3D active appearance models [PDF]

, 2012
This paper presents a method for automatic segmentation of the prostate from transversal T2-weighted images based on 3D Active Appearance Models (AAM). The algorithm consist of two stages.
Heijden, Ferdi van der, Maan, Bianca
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source