Results 61 to 70 of about 174,971 (243)

Precipitable Water Vapor Converted from GNSS-ZTD and ERA5 Datasets for the Monitoring of Tropical Cyclones

IEEE Access, 2020
Tropical cyclones (TCs) are intense rotating storm systems, characterized by strong winds, heavy humidity and storm surges, and usually cause an abnormal increase in regional water vapor during the period of their occurrence.
Qimin He, Zhen Shen, Moufeng Wan, Longjiang Li   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Weighting alternative for water stable isotopes: Statical comparison between station- and firn/ice-records

Polish Polar Research, 2017
It is generally accepted that ice cores archive amount-weighted water stable isotope signals. In order to achieve an improved understanding of the nature of water stable isotope signals stored in ice cores annual δ18O and δ2H averages (i.e.
Hatvani István Gábor, Kern Zoltán
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Method for Building the Grid-Based Atmospheric Weighted Mean Temperature Model Considering the Hourly NSTLR

Atmosphere
The weighted mean temperature (Tm) is a critical parameter for converting zenith wet delay (ZWD) to precipitable water vapor (PWV) in Global Navigation Satellite System (GNSS) meteorology.
Longfei Duan, Hao Tian, Jie Zuo, Caiya Yue, Na Wang   +4 more
doaj   +1 more source

A Global Model for Estimating Tropospheric Delay and Weighted Mean Temperature Developed with Atmospheric Reanalysis Data from 1979 to 2017

Remote Sensing, 2019
Precise modeling of tropospheric delay and weighted mean temperature (Tm) is critical for Global Navigation Satellite System (GNSS) positioning and meteorology.
Zhangyu Sun, Bao Zhang, Yibin Yao
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Retrieving Precipitable Water Vapor Data Using GPS Zenith Delays and Global Reanalysis Data in China

Remote Sensing, 2016
GPS has become a very effective tool to remotely sense precipitable water vapor (PWV) information, which is important for weather forecasting and nowcasting.
Peng Jiang, Shirong Ye, Dezhong Chen, Yanyan Liu, Pengfei Xia   +4 more
doaj   +1 more source

Experimental study on dynamic thermal environment of passenger compartment based on thermal evaluation indexes

Science Progress, 2020
In this article, the thermal environment and the human thermal comfort of car cabin under different driving states in summer were studied experimentally.
Liang Zhang, Liangkui Qi, Jianhua Liu, Qingqing Wu   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source