Results 61 to 70 of about 2,304,873 (264)

Mitigating employee resistance and achieving well-being in digital transformation

Information Technology & People
Purpose Digital transformation is a complex and continuous process that presents significant challenges for companies and employees. Employee resistance, a factor often cited for the failure of digital initiatives, hinders these initiatives and contributes to stress, affecting employee well-being – a connection ...
Alena Valtonen, Mira Holopainen
openaire   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phytogenic synthesis of silver nanoparticles using Lepidium sativum: Characterization and evaluation of its antibacterial potential

Environment Conservation Journal
In this study, an eco-friendly approach was used to successfully synthesize silver nanoparticles (AgNPs) from Lepidium sativum aqueous leaf extract.
Chetna Chauhan, Navneet Bithel
doaj   +1 more source

Skeletal Muscle Mitochondrial Protein Synthesis and Respiration Increase With Low-Load Blood Flow Restricted as Well as High-Load Resistance Training

Frontiers in Physiology, 2018
Purpose: It is well established that high-load resistance exercise (HLRE) can stimulate myofibrillar accretion. Additionally, recent studies suggest that HLRE can also stimulate mitochondrial biogenesis and respiratory function.
Thomas Groennebaek, Nichlas R. Jespersen, Jesper Emil Jakobsgaard, Peter Sieljacks, Jakob Wang, Emil Rindom, Emil Rindom, Robert V. Musci, Hans Erik Bøtker, Karyn L. Hamilton, Benjamin F. Miller, Frank V. de Paoli, Kristian Vissing   +12 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Algorithmic Burnout and Digital Well-Being: Modelling Young Adults’ Resistance to Personalized Digital Persuasion

Societies
In an era when AI systems curate increasingly fine-grained aspects of everyday media use, understanding algorithmic fatigue and resistance is essential for safeguarding user agency.
Stefanos Balaskas, Maria Konstantakopoulou, Ioanna Yfantidou, Kyriakos Komis   +3 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Incidence, identification and antibiotic resistance of Salmonella spp. in the well waters of Tadla Plain, Morocco

Scientific Reports
Concerns about challenges with water availability in the Tadla Plain region of Morocco have grown as a result of groundwater contamination brought on by human activity, climate change, and insufficient groundwater management.
Fatima Zahra Hafiane, Latifa Tahri, Mohamed El Jarmouni, Ahmed M. Reyad, Mohammed Fekhaoui, Mohamed O. Mohamed, Ehab A. Abdelrahman, Samar H. Rizk, Gharieb S. El-Sayyad, Walid F. Elkhatib   +9 more
doaj   +1 more source