Results 81 to 90 of about 2,304,873 (264)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Endocrine responses to low‐load blood flow restricted and high‐load resistance exercise in well‐trained males

Physiological Reports
The present study compared acute testosterone (T), cortisol (C), epinephrine (EPI), norepinephrine (NE), and 22 kDa growth hormone (GH‐22 kDa) responses following low‐load resistance exercise with blood flow restriction (LL‐BFR) and traditional high‐load
Drake A. Eserhaut, Joseph M. DeLeo, Jessica A. Provost, Andrew C. Fry   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Probiotic-infused Mixed Polymeric Nanoparticles Co-incubated with Antibiotics: An Alternative Approach to Combat Drug-resistant Bacteria

The EuroBiotech Journal
The frequent rise of antibiotic-resistant bacteria is due to the increasing use of antibiotics in the healthcare system. Probiotics could offer a potential alternative, although their efficacy tends to be diminished in the presence of antibiotics ...
Thirumalai Anbazhagan, Chatterjee Sampreeti, Gowtham Pemula, Girigoswami Koyeli, Girigoswami Agnishwar   +4 more
doaj   +1 more source

Well-oriented magnesium hydroxide nanoplatelets coating with high corrosion resistance and osteogenesis on magnesium alloy

Journal of Magnesium and Alloys
Magnesium alloys are nontoxic and promising as orthopedic metallic implants, but preparing a biocompatible Mg(OH)2 layer with high corrosion protection ability remains challenging.
Ya Shu, Feng Peng, Zhi-Hui Xie, Qiwen Yong, Liang Wu, Juning Xie, Mei Li   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Corrosion Resistance of Well Steel in a Supercritical Carbon Dioxide Environment in Geothermal Systems Utilizing Depleted Hydrocarbon Reservoirs

Energies
This study evaluates the corrosion behavior of N80 production tubing steel under high-temperature, high-pressure (HTHP) conditions representative of CO2-based geothermal exploitation in depleted hydrocarbon reservoirs.
Mateusz Masłowski, Krzysztof Labus, Marek Czupski, Stefan Ptak   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Well-Posedness of a Viscoelastic Resistive Force Theory and Applications to Swimming

Journal of Nonlinear Science
36 pages, 7 ...
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source