Results 31 to 40 of about 106,969 (295)

Framing Welsh identity

Textes & Contextes, 2008
Welsh Studies as a cross-disciplinary field is growing both in Wales and beyond. Historians, sociologists, political scientists and others are increasingly collaborating in their study of the evolution of Welsh identity.
Moya Jones
doaj   +1 more source

Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor

Communications Biology, 2022
Rational engineering of human spermine oxidase yields crystallizable structures and the design of an allosteric inhibitor.
Elsie Diaz, Suraj Adhikary, Armand W. J. W. Tepper, Daniel Riley, Rodrigo Ortiz-Meoz, Daniel Krosky, Christophe Buyck, Carolina Martinez Lamenca, Josep Llaveria, Lichao Fang, Jay H. Kalin, Vincent N. A. Klaren, Shorouk Fahmy, Paul L. Shaffer, Robert Kirkpatrick, Rodrigo J. Carbajo, Maren Thomsen, Antonietta Impagliazzo   +17 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Population structure and history of the Welsh sheep breeds determined by whole genome genotyping

BMC Genetics, 2015
BackgroundOne of the most economically important areas within the Welsh agricultural sector is sheep farming, contributing around £230 million to the UK economy annually.
Sarah E. Beynon, G. Slavov, Marta Farré, Marta Farré, B. Sunduimijid, K. Waddams, Brian Davies, W. Haresign, J. Kijas, I. Macleod, C. J. Newbold, L. Davies, D. M. Larkin, D. M. Larkin   +13 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

“I Am Sure Aneurin Bevan Would Be Turning in His Grave”. Covid-19 in Wales: Highlighting a Dysfunctional System

Revue Française de Civilisation Britannique, 2023
This paper aims to study how the Covid-19 pandemic has highlighted the weaknesses of the Welsh NHS and more generally public health provision, as its fragmented organisation led to confusing messages from the Welsh and British governments being given ...
Stéphanie Bory
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Engagement and Communication Challenges for a Complex, Multi-nation Research Project: AD|ARC (Administrative Data | Agricultural Research Collection)

International Journal of Population Data Science
The Administrative Data | Agricultural Research Collection (AD|ARC) is a complex research project involving four nations, a mixture of business-level, household-level and person-level data, and diverse partners, stakeholders and audiences.
Freya Pryce, Sarah Lowe, Sian Morrison-Rees, Laura Madden, Paul Caskie, Racheal Loftus   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source