Results 31 to 40 of about 436,672 (299)

Framing Welsh identity

Textes & Contextes, 2008
Welsh Studies as a cross-disciplinary field is growing both in Wales and beyond. Historians, sociologists, political scientists and others are increasingly collaborating in their study of the evolution of Welsh identity.
Moya Jones
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Opening schools in extreme bad weather: guidance for schools (Information document) [PDF]

, 2010
This is a joint publication from the Welsh Assembly Government and the Welsh Local Government Association (WLGA), and provides "advice about what to consider when deciding if a school should close or stay open during extreme bad weather ...

core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Welsh Basin [PDF]

, 2011
The Cambrian rocks of Wales mostly lie within the Avalon composite terrane, apart from a small area of Cambrian rocks of the Monian composite terrane that is discussed in Chapter 9.
Molyneux, S.G., Rushton, A.W.A.
core  

Engagement and Communication Challenges for a Complex, Multi-nation Research Project: AD|ARC (Administrative Data | Agricultural Research Collection)

International Journal of Population Data Science
The Administrative Data | Agricultural Research Collection (AD|ARC) is a complex research project involving four nations, a mixture of business-level, household-level and person-level data, and diverse partners, stakeholders and audiences.
Freya Pryce, Sarah Lowe, Sian Morrison-Rees, Laura Madden, Paul Caskie, Racheal Loftus   +5 more
doaj   +1 more source

“I Am Sure Aneurin Bevan Would Be Turning in His Grave”. Covid-19 in Wales: Highlighting a Dysfunctional System

Revue Française de Civilisation Britannique, 2023
This paper aims to study how the Covid-19 pandemic has highlighted the weaknesses of the Welsh NHS and more generally public health provision, as its fragmented organisation led to confusing messages from the Welsh and British governments being given ...
Stéphanie Bory
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

AD|ARC (Administrative Data | Agricultural Research Collection): Characteristics of farm households participating in agri-environment schemes in Wales, UK.

International Journal of Population Data Science
Objectives • Describe the sociodemographic and farm business characteristics of farming households in Wales that have agri-environment contracts (voluntarily opting-in) without primary farm subsidies (voluntarily opting-out).
Sian Morrison-Rees, Rachael Loftus, Laura Madden, Freya Pryce, Matthew Curds, Paul Caskie   +5 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source