Results 51 to 60 of about 106,969 (295)

Pathways between Probation services and Substance Misuse Treatment Services in Wales

International Journal of Population Data Science
This report investigates the number of individuals who successfully transition into treatment services after a Community Sentence treatment Requirement (CSTR) for an alcohol treatment requirement or a drug rehabilitation requirement in Wales.
Sam Fallick, Josh Dixon, Silvia Colonna
doaj   +1 more source

Relative Age Effects in Welsh Age Grade Rugby Union

, 2015
Relative age effect (RAE) refers to the immediate and long-term consequences of age difference within an age grouping. In sporting contexts, it has been widely shown that those born in the first quarter gain an advantage over those born in the last ...
Jason Lewis, K. Morgan, S. Cooper
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Wales: (Still) a Problem of Translation? Language Choice in Wales at the End of the Anglo-Welsh Era

Iperstoria, 2016
In 1996 the poet  R. S. Thomas claimed that ‘my country, Cymru, to be understood presents a problem of translation, and if it is to maintain a separate and valuable identity, it must continue to do so.’ Thomas, a native speaker of English, and a self ...
David Newbold
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

In the Blood or in the Water? Exploring predictors of Welsh language ability among young people

International Journal of Population Data Science
Objectives Cymraeg 2050 outlines the Welsh Government’s strategy for the promotion and the facilitation of the use of the Welsh language and seeks to have a million Welsh speakers by 2050.
Rhys Davies, Katy Huxley, John Poole
doaj   +1 more source

Welsh Government Flying Start Programme Evaluation Using Linked Data

International Journal of Population Data Science, 2018
Introduction Flying Start (FS) is the Welsh Government’s (WG) flagship Early Years programme for families with children aged less than 4 years of age.
Sarah Lowe, Laura McGuinn, Marcos Quintela, Luke Player   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Impact of the Welsh Government Flying Start programme on children’s BMI and immunisation uptake

International Journal of Population Data Science
Flying Start (FS) is the Welsh Government’s targeted Early Years programme for families with children under 4 years of age who live in some of the most disadvantaged areas of Wales. The programme aims to mitigate the impact of poverty which is linked
Silvia Colonna, Kathryn Helliwell
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source