Results 101 to 110 of about 667,007 (283)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Primary antibodies used in western blotting.
, 2019 Primary antibodies used in western blotting.
Małgorzata Chalimoniuk (4319206) +6 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Análisis de la expresión transgénica en plantas, mediante la técnica Western Blotting
Acta Biológica Colombiana, 2006 La transformación de plantas mediante la tecnología del DNA recombinante es un proceso cuyo resultado debe evaluarse a nivel molecular aplicando técnicas de análisis de la expresión transgénica.
Leidy Andrea Ávila Sánchez +1 more
doaj
Primary antibodies used for western blotting.
, 2019 Primary antibodies used for western blotting.
Ying Zhao (16546) +7 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
List of antibodies used for Western blotting.
, 2019 List of antibodies used for Western blotting.
Mohamed Ali Marey (3135117) +11 more
core +1 more source
Single cell–resolution western blotting [PDF]
, 2016 This protocol describes how to perform western blotting on individual cells to measure cell-to-cell variation in protein expression levels and protein state.
Todd A Duncombe +11 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Antibodies used for Western blotting and Immunohistochemistry.
, 2016 Antibodies used for Western blotting and Immunohistochemistry.
Paula de Carvalho Papa (3203193) +4 more
core +1 more source