Results 161 to 170 of about 1,861,889 (296)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Equine Infectious Anemia Virus in Equids: A Large-Scale Serosurvey in Western Europe. [PDF]

open access: yesAnimals (Basel)
Gonzálvez M   +7 more
europepmc   +1 more source

Drivers of the artiodactyl turnover in insular western Europe at the Eocene-Oligocene Transition. [PDF]

open access: yesProc Natl Acad Sci U S A, 2023
Weppe R   +4 more
europepmc   +1 more source

Subsistence Practices in Western and Northern Europe

open access: gold, 2014
Chris Fowler   +4 more
openalex   +2 more sources

The Economic Impact of the Little Ice Age [PDF]

open access: yes
We investigate by how much the Little Ice Age reduced the harvests on which pre-industrial Europeans relied for survival. We find that weather strongly affected crop yields, but can find little evidence that western Europe experienced long swings or ...
Cormac Ó Gráda, Morgan Kelly
core  

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

open access: yesAdvanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou   +13 more
wiley   +1 more source

Far-reaching hunter-gatherer networks during the Last Glacial Maximum in Western Europe. [PDF]

open access: yesSci Adv
Sánchez de la Torre M   +13 more
europepmc   +1 more source

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