Results 41 to 50 of about 1,843,358 (306)

The Representative Potential of Interest Groups: Internal Voice in Post-Communist and Western European Countries

Politics and Governance, 2023
Why do some interest group systems provide group members with more elaborate voice opportunities than other systems? We argue that evaluating membership voice is important for understanding the representative potential of interest group systems.
Joost Berkhout, Jan Beyers, Marcel Hanegraaff   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

COVID-19: Monitoring the propagation of the first waves of the pandemic

4 open, 2020
Introduction: A phenomenological approach is proposed to monitor the propagation of the first waves of the COVID-19 pandemic. Method: A large set of data collected during the first months of 2020 is compiled into a series of semi-logarithmic ...
Knafo William
doaj   +1 more source

Secondary contact and admixture between independently invading populations of the Western corn rootworm, diabrotica virgifera virgifera in Europe [PDF]

, 2012
The western corn rootworm, Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae), is one of the most destructive pests of corn in North America and is currently invading Europe.
A Estoup, A Estoup, A Rieux, AK Sakai, Aurélie Blin, B Facon, B Facon, B Facon, B Pujol, BS Weir, D Falush, E Lombaert, Eric Lombaert, F Rousset, G Evanno, Gérald Bermond, HC Chiang, IJ Saccheri, J Mallet, J Roman, J Roman, J Turgeon, JC Reif, JJ Kolbe, JK Pritchard, JL Krysan, JM Cornuet, K Csillery, KS Kim, KS Kim, L Gay, Lorenzo Furlan, M Choisy, M Ciosi, M Ciosi, M Raymond, M Raymond, M Slatkin, MA Beaumont, Marc Ciosi, Marco Boriani, ME Gray, MJ Hubisz, MT Cheres, N Miller, NA Rosenberg, NC Ellstrand, NH Barton, NJ Miller, Norman Johnson, O Bossdorf, P Baufeld, P Sunnucks, RF Smith, RJ Petit, S Piry, SR Keller, Stefan Toepfer, T Guillemaud, TF Branson, Thomas Guillemaud, V De Luigi, Y Benjamini   +62 more
core   +5 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Former East, Former West:Post-Socialist Nostalgia and Feminist Genealogies in Today's Europe [PDF]

, 2011
This paper connects current studies of post-socialist nostalgia to the issue of feminist genealogies in the contemporary European context. Studies of post-socialist nostalgia can prove significant not only for the former socialist East - to which they
Bonfiglioli, Chiara
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Why are the railways of Eastern Europe less efficient than those of the West?

Transport Economics and Management
We use a DEA analysis to compare the efficiency of the railways of Western and Eastern Europe and find while most railways of Western Europe are on the efficiency frontier, those of Eastern Europe are typically a long way from it.
Hana Fitzová, Chris Nash
doaj   +1 more source

When Does Sexuality-Based Discrimination Motivate Political Participation?

, 2017
The established consensus in political behavior research is that discrimination by political institutions motivates marginalized groups to vote and protest their conditions.
Page, Douglas D.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source