Results 51 to 60 of about 1,843,358 (306)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Fencing off the east: how the refugee crisis is dividing the European Union [PDF]

, 2015
An analysis of cultural differences between Eastern and Western Europe in the light of the 2015 refugee ...
Culik, Jan
core  

A tale of two capitalisms: preliminary spatial and historical comparisons of homicide rates in Western Europe and the USA [PDF]

, 2009
This article examines comparative homicide rates in the United States and Western Europe in an era of increasingly globalized neoliberal economics. The main finding of this preliminary analysis is that historical and spatial correlations between distinct
Ames, M., Amin, S., Badiou, A., Barclay, G., Barclay, G., Bauman, Z., BBC News, BBC News, BBC News, Boltanski, L., Bonger, W., Cavadino, M., Craig McLean, Dorling, D., Downes, D., Elias, N., Fletcher, J., Fukuyama, F., Garland, D., Gray, J., Green, P., Greenberg, D.F., Hagan, J., Hagedorn, J.M., Hall, S., Hall, S., Hallsworth, S., Held, D., Hirst, P., Hutton, W., Kearon, T., Lane, R., Lasch, C., Lea, J., Luxemburg, R., Merton, R., Messner, S.F., Naughton, B., Ohmae, K., Ohmae, K., Polanyi, K., Rancière, J., Rawls, J., Reiner, R., Reiner, R., Rorty, R., Ruggiero, V., Slotkin, R., Spierenburg, P., Squires, P., Steve Hall, Tawney, R.H., Taylor, I., Todd, E., Tombs, S., Trachtenberg, A., United Nations, Walmsley, R., Wilson, J.Q., Winlow, S., Woodiwiss, M., Young, J., Young, J., Young, J., Zimring, F.E., Zinn, H., Žižek, S.   +66 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

In the Name of Sovereignty. Right-Wing Populism and the Power of the Judiciary in Western Europe

Partecipazione e Conflitto, 2020
This contribution addresses the question of how radical right-wing populist parties in Western Europe frame the issue of judicial power. To date, there have been very few in-depth empirical analyses on the topic – a gap that this article aims to fill ...
Oscar Mazzoleni, Gerrit Voerman
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

ANALYSIS OF THE RELATIONSHIP BETWEEN INNOVATION AND PERFORMANCE. THE CASE OF ROMANIA VERSUS THE COUNTRIES OF WESTERN EUROPE [PDF]

Annals of the University of Craiova: Economic Sciences Series, 2020
The research paper consists in analyzing the relationship between investments in innovation and macroeconomic performance indicators. Recent scientific literature argues that investment in innovation has a direct and positive impact on the performance of
Alin-Ionuț Dorobanțu
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source