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Why Be Funny: The Influence of Social Norms on the Communicative Functions of Humor

Behavioral Sciences
Humor is a valued social activity and, as such, should be influenced by social norms. This investigation examined the relationships between the functions of humor and the theory of normative social behavior.
Nathan Miczo, John C. Meyer
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

The Reporter, April 1993 [PDF]

, 2014
The Reporter is a publication produced by Western Carolina University featuring news, events, and campus community updates for faculty and staff. The publication began in August of 1970 and continues digitally today.
Western Carolina University;
core  

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Feedback and focus: Exploring post-secondary students’ perceptions of feedback, mindfulness, and stress

Cogent Education
Addressing feedback-associated stress as a barrier to learning is increasingly relevant to student success and well-being. Mindfulness practices support stress management for students during the academic feedback process.
Cecilia S. Dong, Erin Isings, Samantha M. Jones, Hugh Samson, Lisa McCorquodale, Thomas G. W. Telfer, Tracey Ropp, Christine E. Bell   +7 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Reporter, April 1991 [PDF]

, 2018
The Reporter is a publication produced by Western Carolina University featuring news, events, and campus community updates for faculty and staff. The publication began in August of 1970 and continues digitally today.
Western Carolina University;
core  

AGENDA SETTING AND FRAMING DURING THE FIRST WAVE OF CORONAVIRUS PANDEMIC: A CONTENT ANALYSIS OF NEWS IN GREEK MEDIA

Anthropological Researches and Studies
Objectives. Drawing heavily on theories focusing on the ways media represent health issues, and more specifically pandemics, the current research seeks to scrutinize the information conveyed by the Greek media to the public regarding the coronavirus ...
Michalis TASTSOGLOU, Sonia KONTOGIANNI, Stamatis POULAKIDAKOS, George PLEIOS   +3 more
doaj   +1 more source