Results 41 to 50 of about 19,928,445 (236)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Western Brass Quintet, February 5, 1982

, 2019
Recorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, Michigan on February 5, 1982, 8:00 p.m., program no. 175 of the School of Music's 1981-1982 season.Western Brass Quintet (Donald Bullock and Stephen Jones,
Western Brass Quintet
core   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Creating Location-Based Mobile Applications for Tourism: A Virtual AR Guide for Western Macedonia

Digital
Augmented reality (AR) applications are currently used in many fields for communication and educational purposes. Tourism is also a sector where augmented reality is used for destination marketing and cultural heritage promotion. This study will focus on
Athanasios Evagelou, Alexandros Kleftodimos, Georgios Lappas   +2 more
doaj   +1 more source

Multi-View Maximum Entropy Clustering by Jointly Leveraging Inter-View Collaborations and Intra-View-Weighted Attributes

IEEE Access, 2018
As a dedicated countermeasure for heterogeneous multi-view data, multi-view clustering is currently a hot topic in machine learning. However, many existing methods either neglect the effective collaborations among views during clustering or do not ...
Pengjiang Qian, Jiaxu Zhou, Yizhang Jiang, Fan Liang, Kaifa Zhao, Shitong Wang, Kuan-Hao Su, Raymond F. Muzic   +7 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Generative AI in Education: Assessing Usability, Ethical Implications, and Communication Effectiveness

Societies
The rapid expansion of generative artificial intelligence tools for textual production, such as ChatGPT, has been accompanied by a proliferation of similar tools used for creating images, audiovisual content, and motion graphics.
Maria Matsiola, Georgios Lappas, Anastasia Yannacopoulou   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Ohio State University Brass Quintet and Western Brass Quintet

, 2017
Recorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, Michigan, February 15, 1974, program no. 144 of the Department of Music’s 1973-1974 season.Ohio State University Brass Quintet (Thomas Battenberg, Richard
Western Brass Quintet, Ohio State University. Brass Quintet   +1 more
core   +2 more sources