Results 81 to 90 of about 641,848 (268)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Augmented Reality for Natural Heritage Education: A Design Framework for Enhancing Indoor Experiences

open access: yesHeritage
Augmented Reality (AR) seamlessly blends the real-world environment with digitally generated content, creating an interactive hybrid experience where both realities coexist.
Athanasios Evagelou   +3 more
doaj   +1 more source

The Usefulness of Related Functions in Web of Science and Scopus

open access: yesEvidence Based Library and Information Practice, 2011
Objective: This study evaluates the effectiveness of the related search functions in Web of Science and Scopus. Web of Science has one related search function (searching by references) whereas Scopus has three related search functions (searching by ...
Dorothy C.P. Char, Isola Ajiferuke
doaj   +1 more source

Media Center contents destroyed by fire [PDF]

open access: yes, 2018
A fire erupted in Hunter Library at Western Carolina University on February 26, 1989. Campus security officer W. R. Holder reported the fire at 5:50 AM and it was contained in the check-out service of the Media Center.

core  

Reporting on Cascadia: The Evolution of a Cross-Border Media Ecosystem [PDF]

open access: yes, 2020
This report examines the news media environment of the U.S./Canada cross-border region known as Cascadia, which includes British Columbia, Washington state, and Oregon.
Border Policy Research Institute, Western Washington University   +1 more
core   +1 more source

Media discourse on jihadist terrorism in Europe [PDF]

open access: yes, 2014
This article analyzes the manner in which European print media discuss jihadist terrorism in Europe. It presents key results from a qualitative analysis of media discourse following three selected attacks in seven European countries in 2010: the attack ...
Reinke de Buitrago, Sybille
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

The Reporter, October 1988 [PDF]

open access: yes, 2017
The Reporter is a publication produced by Western Carolina University featuring news, events, and campus community updates for faculty and staff. The publication began in August of 1970 and continues digitally today.
Western Carolina University;
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

The Reporter, July 2009 [PDF]

open access: yes, 2017
The Reporter is a publication produced by Western Carolina University featuring news, events, and campus community updates for faculty and staff. The publication began in August of 1970 and continues digitally today.
Western Carolina University;
core  

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