Results 71 to 80 of about 19,928,445 (236)

Extended Reality Applications in Environmental Education: A Field Learning Approach to Understanding Lake Ecosystems

open access: yesApplied Sciences
This study examines the design and pedagogical evaluation of Extended Reality (XR) applications, with a primary focus on location-based Augmented Reality (AR).
Athanasios Evagelou   +1 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Augmented Reality for Natural Heritage Education: A Design Framework for Enhancing Indoor Experiences

open access: yesHeritage
Augmented Reality (AR) seamlessly blends the real-world environment with digitally generated content, creating an interactive hybrid experience where both realities coexist.
Athanasios Evagelou   +3 more
doaj   +1 more source

The Usefulness of Related Functions in Web of Science and Scopus

open access: yesEvidence Based Library and Information Practice, 2011
Objective: This study evaluates the effectiveness of the related search functions in Web of Science and Scopus. Web of Science has one related search function (searching by references) whereas Scopus has three related search functions (searching by ...
Dorothy C.P. Char, Isola Ajiferuke
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

The Effects of Humor in the Media: A Critical Review of Experimental Research

open access: yesBehavioral Sciences
Humor has long been of interest to media effects scholars. As meta-analyses and systematic reviews accumulate, there is a need to continue scrutinizing the means of knowledge production.
Nathan Miczo, Danyang Zhao
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Western Wind Quintet, November 2, 1979

open access: yes, 2018
Recorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, Michigan, November 2, 1979, program no. 68 of the Department of Music's 1979-1980 season.Western Wind Quintet (Charles Osborne, flute ; Robert Humiston ...
Western Wind Quintet
core   +2 more sources

Home - About - Disclaimer - Privacy