Results 201 to 210 of about 17,753,198 (231)

A combined microhydrodynamics–polymer adsorption analysis for elucidation of the roles of stabilizers in wet stirred media milling

International Journal of Pharmaceutics, 2012
Although polymers and surfactants are commonly used as stabilizers to impart physical stability to the suspensions produced by wet stirred media milling of poorly water-soluble drugs, scant information is available in pharmaceutical literature regarding their impact on the breakage kinetics.
Ecevit Bilgili, Afolawemi Afolabi
exaly   +3 more sources

Nano-bio interface between As4S4 nanoparticles and albumin influenced by wet stirred media milling

International Journal of Pharmaceutics, 2023
Arsenic sulfide (As4S4) nanoparticles have been intensively researched as a promising drug in a cancer treatment. For the first time, the interaction between As4S4 and bovine serum albumin has been studied in this paper. Initially, the sorption kinetics of albumin on the surface of nanoparticles was investigated.
Zdenka Lukáčová Bujňáková, Inna Melnyk, Erika Dutková, Rastislav Varhač, Jana Jakubíková, Danka Cholujová, Erika Tóthová, Liudmyla Storozhuk, Jaroslav Briančin   +8 more
openaire   +2 more sources

Effects of bead packing limit concentration on microhydrodynamics-based prediction of breakage kinetics in wet stirred media milling

Powder Technology, 2022
Ecevit Bilgili, Gulenay Guner
exaly   +2 more sources

Model based process optimization of nanosuspension preparation via wet stirred media milling

Powder Technology, 2018
Abstract The present study focuses on model based parameter optimization of nanosuspension preparation via wet stirred media milling. Based on experimental data of nanomilling a crystalline organic material, two different approaches for process optimization were evaluated: The stress model for stirred media mills, introduced by Kwade, was compared to
Arno Kwade, Frederik Flach
exaly   +2 more sources

Production of sub-micron particles by wet comminution in stirred media mills

Journal of Materials Science, 2004
A joined research project between the Technical University of Braunschweig and the Technical University of Munchen investigates the possibilities for the production of stable product suspensions in a particle size range smaller than 100 nm. In this paper results for comminution of fused corundum showing the influence of the electrostatic stabilization ...
S. Mende, F. Stenger, W. Peukert, J. Schwedes   +3 more
openaire   +1 more source

A microhydrodynamic rationale for selection of bead size in preparation of drug nanosuspensions via wet stirred media milling

International Journal of Pharmaceutics, 2017
Although wet stirred media milling has proven to be a robust process for producing nanoparticle suspensions of poorly water-soluble drugs and thereby enhancing their bioavailability, selection of bead size has been largely empirical, lacking fundamental rationale.
Meng Li, Ecevit Bilgili
exaly   +3 more sources

Mill, material, and process parameters – A mechanistic model for the set-up of wet-stirred media milling processes

Advanced Powder Technology, 2019
Abstract Stirred media milling is frequently used to generate nanoparticles for industrial applications such as paints, inks, and food or for the life sciences. Each product suspension has different requirements and therefore different material and formulation parameters.
Sandra Breitung-Faes, Arno Kwade
exaly   +2 more sources

Use of an Enhanced Stress Model for the Optimization of Wet Stirred Media Milling Processes

Chemical Engineering and Technology, 2014
AbstractWet grinding processes, especially in terms of nanoparticle production, are extremely energy intensive, and for hard and abrasive product materials, high grinding media wear is produced. In order to minimize energy consumption, the choice of the process parameters is crucial. The decision on the process parameters often depends on experience or
Sandra Breitung-Faes, Arno Kwade
exaly   +2 more sources

An Enthalpy-Balance Model for Timewise Evolution of Temperature during Wet Stirred Media Milling of Drug Suspensions

Pharmaceutical Research, 2022
Nanosuspensions have been used for enhancing the bioavailability of poorly soluble drugs. This study explores the temperature evolution during their preparation in a wet stirred media mill using a coupled experimental-enthalpy balance approach.Milling was performed at three levels of stirrer speed, bead loading, and bead sizes.
Gulenay Guner, Sherif Elashri, Mirsad Mehaj, Natasha Seetharaman, Helen F. Yao, Donald J. Clancy, Ecevit Bilgili   +6 more
openaire   +2 more sources

Characterization of highly accessible cellulose microfibers generated by wet stirred media milling

Carbohydrate Polymers, 2011
Abstract In this work, highly accessible cellulose microfibers produced from kraft wood pulp by a novel method based on a single mechanical treatment with a wet stirred media mill were characterized. The high mechanical stress of milling resulted in the complete disintegration of the fiber cell wall and produced cellulose microfibers with a length of
Liimatainen Henrikki, Sirviö Juho, Haapala Antti Tapio, Niinimäki Jouko, Hormi Osmo Eelis Olavi   +4 more
openaire   +1 more source