Results 211 to 220 of about 17,753,198 (231)
European Journal of Pharmaceutical Sciences, 2014 Wet stirred media milling has proven to be a robust process for producing nanoparticle suspensions of poorly water-soluble drugs. As the process is expensive and energy-intensive, it is important to study the breakage kinetics, which determines the cycle time and production rate for a desired fineness.
Ecevit Bilgili, Afolawemi Afolabi
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Ultrasound assisted wet stirred media mill of high concentration LiFePO₄ and catalysts
The Canadian Journal of Chemical Engineering, 2019AbstractWet media mills grind solids to the nanometric size and the performance of the mills depends on solids loading, particle morphology, surfactant concentration, and material characteristics. As the particle size decreases, they tend to form clusters that reduce the grinding efficiency.
He Li +6 more
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Wet comminution in stirred media mills — research and its practical application
Powder Technology, 1999Abstract The importance of stirred media mills in various industries and in research is steadily increasing. The comminution process in these mills is determined mainly by the number of stress events in the grinding chamber and by the intensity acting at these stress events: for a certain stress intensity a certain relation between the product ...
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European Journal of Pharmaceutics and BiopharmaceuticsThis study explores the effects of stirrer speed, bead loading, and bead size on the evolution of mill outlet temperature during the wet stirred media milling (WSMM) of fenofibrate suspensions using crosslinked polystyrene (CPS) beads. Key parameters, including mill outlet temperature, particle size, suspension viscosity, and power consumption, were ...
Ecevit Bilgili +2 more
exaly +3 more sources
Chemical Engineering Science, 2006
Abstract The present study concerns the production of pigment nanoparticles in a wet-batch stirred media mill with polymeric media. The breakage kinetics and mechanisms were investigated using size-discrete population balance models (PBMs). The temporal variation of the particle size distribution was measured via dynamic light scattering. Considering
Ecevit Bilgili +2 more
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Abstract The present study concerns the production of pigment nanoparticles in a wet-batch stirred media mill with polymeric media. The breakage kinetics and mechanisms were investigated using size-discrete population balance models (PBMs). The temporal variation of the particle size distribution was measured via dynamic light scattering. Considering
Ecevit Bilgili +2 more
openaire +1 more source
Scaling Wet Fine Grinding Processes of Organic Particles Using Stirred Media Mills
Chemie Ingenieur Technik, 2017AbstractThis study presents an approach to scale up wet fine grinding processes of organic particles using stirred media mills. The process transfer is based on the calculation of grinding‐relevant energy, which is transferred to the product by a model theory derived from mill‐related values, especially geometric aspects.
Frederik Flach +2 more
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Powder Technology, 2006
Wet ultra-fine grinding of a limestone powder (< 100 μm) has been investigated in a stirred media mill with respect to the effect of slurry rheology. The grinding results obtained by various parameters (i.e., molecular weight of a dispersant, solids concentration, additive dosage, addition method and beads load) are evaluated in terms of energy ...
He, Mingzhao +2 more
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Wet ultra-fine grinding of a limestone powder (< 100 μm) has been investigated in a stirred media mill with respect to the effect of slurry rheology. The grinding results obtained by various parameters (i.e., molecular weight of a dispersant, solids concentration, additive dosage, addition method and beads load) are evaluated in terms of energy ...
He, Mingzhao +2 more
openaire +4 more sources
Drug Development and Industrial Pharmacy, 2012
Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant information is available regarding the continuous production of drug nanoparticles via wet media milling.
Alexandre, Monteiro +2 more
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Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant information is available regarding the continuous production of drug nanoparticles via wet media milling.
Alexandre, Monteiro +2 more
openaire +2 more sources
International Journal of Biological Macromolecules
Polysaccharide-based nanoparticles have emerged as novel stabilizers in Pickering emulsions. Techniques such as wet-stirred media milling (WSMM) to obtain starch nanoparticles have not been widely reported, in contrast to the chemical hydrolysis methods.
Pablo Daniel Ribotta +2 more
exaly +3 more sources
Polysaccharide-based nanoparticles have emerged as novel stabilizers in Pickering emulsions. Techniques such as wet-stirred media milling (WSMM) to obtain starch nanoparticles have not been widely reported, in contrast to the chemical hydrolysis methods.
Pablo Daniel Ribotta +2 more
exaly +3 more sources
Chemical Engineering Science, 2015
Abstract Wet fine grinding is an important unit process in various industries. In the present work two different stirred media mills (one with a cylindrical stirrer; one with a disc stirrer) and a planetary ball mill are investigated using coupled CFD (computational fluid dynamics) and DEM (discrete element method) simulations.
S. Beinert +3 more
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Abstract Wet fine grinding is an important unit process in various industries. In the present work two different stirred media mills (one with a cylindrical stirrer; one with a disc stirrer) and a planetary ball mill are investigated using coupled CFD (computational fluid dynamics) and DEM (discrete element method) simulations.
S. Beinert +3 more
openaire +1 more source