Results 51 to 60 of about 2,696,264 (156)
, 2010 BACKGROUND: Valproate is a standard treatment for bipolar disorder and a first-line mood stabilizer. The molecular mechanisms underlying its actions in bipolar disorder are unclear.
Ishigaki, Shinsuke +5 more
core +1 more source
Impairment of visual function and retinal ER stress activation in Wfs1-deficient mice.
PLoS ONE, 2014 Wolfram syndrome is an early onset genetic disease (1/180,000) featuring diabetes mellitus and optic neuropathy, associated to mutations in the WFS1 gene.
Delphine Bonnet Wersinger +6 more
doaj +1 more source
Haplotype analysis of the 3’ UTR SNPs of the WFS1 gene.
, 2015 Haplotype analysis of the 3’ UTR SNPs of the WFS1 gene.
Anikó Somogyi (362442) +7 more
core +1 more source
The miR-668 binding site variant rs1046322 on WFS1 is associated with obesity in Southeast Asians
Frontiers in Endocrinology, 2023 The Wolfram syndrome 1 gene (WFS1) is the main causative locus for Wolfram syndrome, an inherited condition characterized by childhood-onset diabetes mellitus, optic atrophy, and deafness.
Maha M. Hammad +10 more
doaj +1 more source
RGC cell density in Wfs1−/− mice.
, 2014 Brn3a and total nuclei were counted in nerve fiber layer of 12 month retinal sections (A). RGC cell density is given as average Brn3a cell nuclei in 1000 pixel segments of retina (B).
Nesrine Benkafadar (563168) +6 more
core +1 more source
Frontiers in Neuroscience, 2013 It has been shown that mutations in the WFS1 gene make humans more susceptible to mood disorders. Besides that, mood disorders are associated with alterations in the activity of serotonergic and noradrenergic systems.
Tanel eVisnapuu +21 more
doaj +1 more source
JCI Insight, 2022 Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration.
Rie Asada Kitamura +16 more
doaj +1 more source
Advanced Science, EarlyView.Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang +7 more
wiley +1 more source
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells [PDF]
, 2010 Wolfram syndrome is an autosomal-recessive disorder characterized by insulin-dependent diabetes mellitus, caused by nonautoimmune loss of beta cells, and neurological dysfunctions.
Lipson, Kathryn L. +10 more
core +1 more source