Results 61 to 70 of about 2,517,817 (182)

WFS1 promoter is activated by valproate.

, 2013
SH-SY5Y cells were transfected with a reporter plasmid containing 500 bases of the WFS1 promoter driving the luciferase gene (pGL3-WFS1-long), a control reporter plasmid containing only 60 bases of the WFS1 promoter (pGL3-WFS1-short), or control plasmid (
Shinsuke Ishigaki (133010), Tadafumi Kato (19147), Sonya G. Fonseca (375193), Chihiro Kakiuchi (375191), Christine M. Oslowski (375192), Fumihiko Urano (40695)   +5 more
core   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Silencing of theWFS1gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage

, 2013
The gene WFS1 encodes a protein with unknown function although its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes.
Cathy Fern, Ivask, M., Mithu Guha, Overall, Rupert W, Soomets, U., Ivask, Marilin, Ursel Soomets, Guha, Mithu, Leo C. Schalkwyk, Schalkwyk, L.C., Marilin Ivask, Vasar, Eero, Rupert W. Overall, Vasar, E., Soomets, Ursel, Kõks, S., Fernandes, Cathy; id_orcid, Fernandes, Cathy, Guha, M., Kõks, Sulev, Schalkwyk, Leo C, Sulev Kõks, Overall, R.W., Fernandes, C., Eero Vasar   +24 more
core   +1 more source

Characterization of Novel WFS1 Variants in Three Diabetes Pedigrees

Journal of Diabetes
Background Mutations in the WFS1 gene are implicated in Wolfram syndrome (WS), Wolfram‐like syndrome (WFLS), and maturity‐onset diabetes of the young (MODY).
ChangQing Liu, HangYu Fang, Dong Wang, YiPing Cheng, Ping Shi, ChunXiao Yu, XiaoHong Li, Hui Zhao, Wei Hou, ZhenKui Guo, Chao Xu, QingBo Guan   +11 more
doaj   +1 more source

The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers

Journal of Diabetes Investigation, EarlyView.
Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen, Yi‐fan Shi, Xin‐yue Zhang, Jing‐yue Zhang, Shi‐mao Zhang, Heng‐xia Zhao, De‐liang Liu   +6 more
wiley   +1 more source

The molecular effect of a polymorphic microRNA binding site of Wolfram syndrome 1 gene in dogs

BMC Genetics, 2020
Background Although the molecular function of wolframin remains unclear, the lack of this protein is known to cause stress in the endoplasmic reticulum.
Dora Koller, Eniko Kubinyi, Zsuzsanna Elek, Helga Nemeth, Adam Miklosi, Maria Sasvari-Szekely, Zsolt Ronai   +6 more
doaj   +1 more source

WFS1 Gene–associated Diabetes Phenotypes and Identification of a Founder Mutation in Southern India

The Journal of Clinical Endocrinology & Metabolism, 2022
Abstract Context Wolfram syndrome (WFS) is a rare autosomal recessive disorder characterized by juvenile-onset diabetes, diabetes insipidus, optic atrophy, deafness, and progressive neurodegeneration. However, due to the progressive nature of the disease and a lack of complete clinical manifestations,
Aaron Chapla, Jabasteen Johnson, Sophy Korula, Nisha Mohan, Anish Ahmed, Deny Varghese, Parthiban Rangasamy, Lavanya Ravichandran, Felix Jebasingh, Krishna Kumar Agrawal, Noel Somasundaram, Asha Hesarghatta Shyamasunder, Sarah Mathai, Anna Simon, Sujeet Jha, Subhankar Chowdry, Radha Venkatesan, Palany Raghupathy, Nihal Thomas   +18 more
openaire   +2 more sources

An Integrated and Robust Deep Learning Framework for Denoising and Analyzing Single‐Cell Spatial Transcriptomics

Advanced Intelligent Systems, Volume 8, Issue 8, August 2026.
Single‐cell Spatial Transcriptomics Analysis and Denoising Engine is introduced as a unified deep learning framework that jointly performs denoising, clustering, and gene prioritization in spatial transcriptomics. By integrating linear and nonlinear representations within a dual‐channel architecture, it improves robustness and accuracy, uncovers ...
Yaxuan Cui, Yang Cui, Ruheng Wang, Xin Zeng, Zheyong Zhu, Ding Yi, Ruihua Guo, Tetsuya Sakurai, Kenta Nakai, Xiucai Ye, Leyi Wei, Yong Chen   +11 more
wiley   +1 more source

Impaired Compensatory Vasodilatory Effect Mediated by Wolfram Syndrome 1 and Corticotropin-Releasing Hormone Family Peptides in 17α-Ethynylestradiol-Induced Intrahepatic Cholestasis Pregnant Rats When Under Additional Acute Hypoxia Stress

Maternal-Fetal Medicine, 2022
. Objective:. To investigate the possible regulatory mechanism of corticotropin-releasing hormone (CRH), urocortin (UCN), and Wolfram syndrome 1 (WFS1) in 17α-ethynylestradiol (EE)-induced intrahepatic cholestasis pregnant rats and its ischemia ...
Tingting Xu, Daijuan Chen, Xixi Deng, Yongchi Zhan, Fan Zhou, Xiaodong Wang, Dandan Shi   +6 more
doaj   +1 more source

Regional Functional Molecular Profiles Within the Mammalian Cortex: A Commentary on Limbic Mesocortex

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
Two lateral mouse brain sagittal sections labeled, respectively, for Lypd1 (A) and Kcnab3 (B). (A) Lypd1 labels positively cortical Layers 2 and 5 (less heavily), but only at limbic mesocortical sites, forming the limbic ring that separates the unlabeled isocortex (IsoCx) from the unlabeled hippocampal and olfactory allocortex (Hi, Sub, ERh; OlfCx ...
Luis Puelles, Elena Garcia‐Calero
wiley   +1 more source