Results 61 to 70 of about 2,696,264 (156)

Seminal Biomarkers and Sperm Proteomic Signatures Differentiate Acute and Chronic Male Accessory Gland Inflammation

Andrology, EarlyView.
ABSTRACT Background Male accessory gland inflammation (MAGI) comprises a heterogeneous group of inflammatory conditions that may differentially affect the seminal microenvironment and sperm function. However, whether transrectal ultrasound (TRUS)‐defined MAGI phenotypes correspond to distinct biological profiles remains insufficiently characterized ...
Emanuela Teveroni, Fiorella Di Nicuolo, Giorgia Mazzuccato, Alessandro Oliva, Emanuele Pierpaolo Vodola, Francesca Mancini, Carla Di Nardo, Edoardo Vergani, Michela Cicchinelli, Federica Iavarone, Cassandra Serantoni, Giuseppe Maulucci, Alessia Riente, Alfredo Pontecorvi, Andrea Urbani, Domenico Milardi, Silvia Baroni   +16 more
wiley   +1 more source

Characterization of Novel WFS1 Variants in Three Diabetes Pedigrees

Journal of Diabetes
Background Mutations in the WFS1 gene are implicated in Wolfram syndrome (WS), Wolfram‐like syndrome (WFLS), and maturity‐onset diabetes of the young (MODY).
ChangQing Liu, HangYu Fang, Dong Wang, YiPing Cheng, Ping Shi, ChunXiao Yu, XiaoHong Li, Hui Zhao, Wei Hou, ZhenKui Guo, Chao Xu, QingBo Guan   +11 more
doaj   +1 more source

Integrated scRNA‐Seq and Spatial Transcriptomics Reveal CHPF and GPC1 as Markers of Cancer‐Associated Fibroblast–Dominant Domains in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Spatial heterogeneity in the colorectal cancer (CRC) tumor microenvironment (TME) is closely related to stromal organization and may influence treatment‐related features. In this study, we integrated single‐cell RNA sequencing and spatial transcriptomic data from CRC tissues to examine cancer‐associated fibroblast (CAF)‐dominant spatial ...
Yuan‐jie Liu, Qian‐wen Ye, Hui Zhang, Ning Yang, Yang Li, Jie‐pin Li   +5 more
wiley   +1 more source

The molecular effect of a polymorphic microRNA binding site of Wolfram syndrome 1 gene in dogs

BMC Genetics, 2020
Background Although the molecular function of wolframin remains unclear, the lack of this protein is known to cause stress in the endoplasmic reticulum.
Dora Koller, Eniko Kubinyi, Zsuzsanna Elek, Helga Nemeth, Adam Miklosi, Maria Sasvari-Szekely, Zsolt Ronai   +6 more
doaj   +1 more source

The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1816-1834, October 2026.
Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen, Yi‐fan Shi, Xin‐yue Zhang, Jing‐yue Zhang, Shi‐mao Zhang, Heng‐xia Zhao, De‐liang Liu   +6 more
wiley   +1 more source

Testing the Role of Wfs1 in Calcium Regulation in Drosophila Cells [PDF]

, 2021
The purpose of the project is to knock out the Wfs1 gene in Drosophila (fruit fly) cells and test the hypothesis that this gene is involved in regulating intracellular calcium levels.
Scott, Briana, Lee, Alyandra
core  

Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders [PDF]

, 2005
Wolfram syndrome gene (WFS1) has been suggested to have a role in the susceptibility for mood disorders. A 26-fold increased risk for psychiatric disorders in WFS1 mutation carriers has been suggested. In this study we tested the hypothesis that the WFS1
Maron, E., Shlik, J., Tammekivi, V., Vabrit, K., Vasar, E., Nikopensius, T., Metspalu, A., Heinaste, E., Kõks, S., Hallast, P., Koido, K., Kurg, A., Vasar, V., Altmäe, S.   +13 more
core  

A nonsynonymous mutation in the WFS1 gene in a Finnish family with age-related hearing impairment

, 2017
Wolfram syndrome (WS) is caused by recessive mutations in the Wolfram syndrome 1 (WFS1) gene. Sensorineural hearing impairment (HI) is a frequent feature in WS and, furthermore, certain mutations in WFS1 cause nonsyndromic dominantly inherited low ...
Elina Mäki-Torkko, Samuli Hannula, Sorri, Martti,, Kari Majamaa, Kytövuori, Laura,, Hannula, Samuli,, Majamaa, Kari,, Martti Sorri, Laura Kytövuori, Mäki-Torkko, Elina,   +9 more
core   +1 more source

Common variants in WFS1 confer risk of type 2 diabetes [PDF]

, 2007
We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies.
Sally L Debenham, Manjinder S Sandhu, Daly, Allan, Allan Daly, Weedon, Michael N., Hana Lango, Morris, Andrew D., Nicholas J Wareham, Richard Sherva, Timothy M Frayling, Mark Walker, Debenham, Sally L., Palmer, Colin N A, Palmer, Colin N.A.; id_orcid, Sandhu, Manjinder S., Hattersley, Andrew T., Permutt, M. Alan, Glaser, Benjamin, Graham Hitman, Wareham, Nicholas J., Fawcett, Katherine A., Colin N A Palmer, Inês Barroso, Sherva, Richard, Andrew D Morris, Tavendale, Roger, Michael N Weedon, Ilana Blech, Walker, Mark, Paul D Pharoah, Pharoah, Paul D., Hitman, Graham, Blech, Ilana, Mark I McCarthy, Barroso, Inês, Wasson, Jon, Kimber, Charlotte, Frayling, Timothy M., Roger Tavendale, Andrew T Hattersley, M Alan Permutt, Lango, Hana, Benjamin Glaser, Neumann, Rosalind J., McCarthy, Mark I., Jon Wasson, Rosalind J Neumann, Katherine A Fawcett, Charlotte Kimber   +48 more
core   +1 more source

Impaired Compensatory Vasodilatory Effect Mediated by Wolfram Syndrome 1 and Corticotropin-Releasing Hormone Family Peptides in 17α-Ethynylestradiol-Induced Intrahepatic Cholestasis Pregnant Rats When Under Additional Acute Hypoxia Stress

Maternal-Fetal Medicine, 2022
. Objective:. To investigate the possible regulatory mechanism of corticotropin-releasing hormone (CRH), urocortin (UCN), and Wolfram syndrome 1 (WFS1) in 17α-ethynylestradiol (EE)-induced intrahepatic cholestasis pregnant rats and its ischemia ...
Tingting Xu, Daijuan Chen, Xixi Deng, Yongchi Zhan, Fan Zhou, Xiaodong Wang, Dandan Shi   +6 more
doaj   +1 more source