Results 81 to 90 of about 2,517,817 (182)
Haplotype analysis of the 3’ UTR SNPs of the WFS1 gene.
, 2015 Haplotype analysis of the 3’ UTR SNPs of the WFS1 gene.
Anikó Somogyi (362442) +7 more
core +1 more source
Brain and Behavior, Volume 16, Issue 5, May 2026.ABSTRACT Purpose Alzheimer's disease (AD) is a progressive neurodegenerative disorder involving amyloid‐β deposition, tau hyperphosphorylation, oxidative stress, and neuroinflammation. This review systematically evaluates the neuroprotective effects of Litchi chinensis and its phytochemicals against AD, focusing on modulation of Aβ accumulation, tau ...
Emon Mia +11 more
wiley +1 more source
Diabetic Medicine, Volume 43, Issue 5, May 2026.Abstract Aims Maturity‐Onset Diabetes of the Young (MODY) results from a single‐gene defect. This study aimed to determine the minimal prevalence, screening indicators, as well as clinical characteristics of MODY in the Czech Republic based on data from 25 years of the nationwide registry.
Petra Dusatkova +8 more
wiley +1 more source
RGC cell density in Wfs1−/− mice.
, 2014 Brn3a and total nuclei were counted in nerve fiber layer of 12 month retinal sections (A). RGC cell density is given as average Brn3a cell nuclei in 1000 pixel segments of retina (B).
Nesrine Benkafadar (563168) +6 more
core +1 more source
Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis
Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 846-858, April 2026.Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic +4 more
wiley +1 more source
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in UK populations
Mutations in the WFS1 gene cause beta-cell death, resulting in a monogenic form of diabetes known as Wolfram syndrome. The role of variation in WFS1 in type 2 diabetes susceptibility is not known. We sequenced the WFS1 gene in 29 type 2 diabetic probands
Walker M; Minton JAL; Hattersley AT; Owen K; McCarthy MI; Latif F; Barrett T; Frayling TM
core +5 more sources
Defective Endoplasmic Reticulum–Mitochondria Connection Is a Hallmark of Wolfram Syndrome
Contact, 2019 Interactions between endoplasmic reticulum (ER) and mitochondria are key components of essential cellular functions. Indeed, these membrane appositions are necessary for proper Ca 2+ transfer from ER to mitochondria, to regulate lipid metabolism ...
Benjamin Delprat +2 more
doaj +1 more source
Sex and life experience shape locus coeruleus pretangle tau pathology
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract INTRODUCTION Alzheimer's disease features early a pathology in the locus coeruleus (LC), yet how sex and life experience shape LC vulnerability remains poorly understood. METHODS We expressed pseudophosphorylated human tau (htauE14) in LC neurons of TH‐Cre rats and exposed both sexes to early‐ or late‐life enrichment or stress.
Zia Hasan +10 more
wiley +1 more source
Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton +12 more
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.This systematic review synthesizes evidence from published studies, GWAS and grey literature (patents) to show that CAMK1D is implicated in diabetes, obesity, insulin resistance and altered feeding behaviours, with diagnostic potential and mechanistic relevance through regulatory binding and tissue‐specific effects.
Livio Tarchi +13 more
wiley +1 more source