Integrative analysis of transcriptomics and drug-target networks identifies SMN1 as a novel biomarker and therapeutic target for amyotrophic lateral sclerosis. [PDF]
J Genet Eng BiotechnolEshak D, Arumugam M.
europepmc +1 more source
Immune-related inflammatory gene in hypertrophic scar: prognostic and molecular mechanisms via integrated machine learning-WGCNA analysis [PDF]
Yufang Liu +3 more
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Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Immune checkpoint regulators can improve neurological functions in Alzheimer's disease. However, it remains blurred whether these regulators may ameliorate temporal lobe epilepsy (TLE) and TLE‐related cognitive impairment. This study analyzed the bulk transcriptomic data of human TLE hippocampi by bioinformatics.
Man Li +3 more
wiley +1 more source
A prognostic nomogram for colorectal cancer: integrating blood microbiome and clinical factors. [PDF]
J Gastrointest OncolYang H, Liu X, Yuan D, Li H, Mu X.
europepmc +1 more source
Structural variation drives rhizome innovation and adaptive divergence in sister Medicago species
Journal of Integrative Plant Biology, Volume 68, Issue 2, Page 406-424, February 2026.Chromosome‐scale genome analysis, population resequencing, stress‐responsive transcriptomes and functional assays showed that coding and regulatory structural variants, especially gene duplications and noncoding presence‐absence variants, underlie rhizome formation in alpine Medicago archiducis‐nicolai and contrasting xeric adaptation in its non ...
Hongyin Hu +14 more
wiley +1 more source
Integrated Transcriptomic Analysis Identifies Core Hub Genes Regulating Mammary Gland Traits (Milk Quality/Lactation) in Dairy Livestock: <i>Bos taurus</i> and <i>Ovis aries</i>. [PDF]
Genes (Basel)Zhang Q +7 more
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Comprehensive analysis of immunogenic cell death-related gene and construction of prediction model based on WGCNA and multiple machine learning in severe COVID-19 [PDF]
Chunyu Li +7 more
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Sex‐specific ethylene responses drive floral sexual plasticity in Cannabis sativa
The Plant Journal, Volume 125, Issue 3, February 2026.SUMMARY Cannabis sativa L. exhibits pronounced sexual plasticity in which both XX and XY plants can undergo floral phenotypic sex reversal in response to ethylene modulation, yet the underlying molecular mechanisms remain poorly defined. Here, we present the most extensive multi‐omic analysis of ethylene‐induced sex change in C.
Adrian S. Monthony +5 more
wiley +1 more source
Life-cycle-related gene expression patterns in the brown algae. [PDF]
ElifeRatchinski P +4 more
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The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Mechanistic pathways of PIK3R1 in skin aging and rejuvenation were analyzed by bioinformatics approach and Gene Expression Omnibus database. Compared with young skin, PIK3R1 was differentially expressed in aged and IPL rejuvenated skin. Coexpression and network analyses revealed that PIK3R1 jointly participated in skin aging and rejuvenation via PI3K ...
Zhike Zhou +8 more
wiley +1 more source