Results 231 to 240 of about 47,201 (334)

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Integrative analysis via bioinformatics and machine learning identifies SERPING1 as a biomarker candidate for major depressive disorder. [PDF]

BMC Psychiatry
Yuan X, Wang T.
europepmc   +1 more source

Identification of soft-thresholding power (β) in WGCNA and module detection for

Zahra Soltani (2898647), Ali Moghadam (3148116), Mohammadreza Shamekh (21627306)   +2 more
openalex   +1 more source

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole‐Blood RNA Transcriptome

Arthritis &Rheumatology, Volume 78, Issue 5, Page 1124-1133, May 2026.
Objective Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)–positive patients using whole‐blood transcriptomics.
Amala Ambati, Feiyang Ma, Katarina Kmetova, Sherwin Navaz, Claire K. Hoy, Cyrus Sarosh, Ajay Tambralli, Erika Navarro‐Mendoza, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Alí Duarte‐García, Jason S. Knight, Yu Zuo   +13 more
wiley   +1 more source

Analysis of the Potential Link Between Dermatomyositis and Cancer

Journal of Inflammation Research
Jianwei Guo,1,2,* Tianyi Lei,1,3,* Xiang Yu,1,3 Peng Wang,1,2 Hongyuan Xie,1,3 Guilin Jian,1,4 Quanbo Zhang,1,2,* Yufeng Qing1,3 1Research Center of Hyperuricemia and Gout, Affiliated Hospital of North Sichuan Medical College, Nanchong ...
Guo J, Lei T, Yu X, Wang P, Xie H, Jian G, Zhang Q, Qing Y   +7 more
doaj  

Identification of a biologically coherent three gene immune signature predictive of immunotherapy benefit in gastric adenocarcinoma. [PDF]

Discov Oncol
Fan R, Wang J, Xu L, Jin Y.
europepmc   +1 more source

Identification of key pathways and genes in different types of chronic kidney disease based on WGCNA

, 2019
Yuhe Guo, Junjie Ma, Lanyan Xiao, Jiali Fang, Guanghui Li, Lei Zhang, Lu Xu, Xingqiang Lai, Guanghui Pan, Zheng Chen   +9 more
openalex   +2 more sources

Novel Insights Into the Association Between Parkinson's Disease and Constipation: Role of SHMT2 as a Promising Biomarker

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
This study integrated bioinformatics analysis, cellular models, and PD/constipation mouse models to identify SHMT2 as a key shared biomarker linking Parkinson's disease and constipation. SHMT2 upregulation was validated in dopaminergic neurons and the enteric nervous system, highlighting its potential role in gut–brain axis dysfunction.
Jiehua Su, Kaixun Huang, Xiuna Jing, Xiaohuan Liu, Cheng Wen, Rulin Geng, Zhuoying Lai, Zhijia Ruan, Yiqiang Zhan, Danyu Lin, Enxiang Tao   +10 more
wiley   +1 more source

Bioinformatics combined with machine learning for potential biomarker screening and immune infiltration analysis in neonatal sepsis. [PDF]

Front Pediatr
Liu N, Tan Z.
europepmc   +1 more source

RNA binding protein ZFP36L1 promotes ferroptosis in chronic rhinosinusitis by destabilizing CAMK2A mRNA and impairing mitochondrial quality control

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
This graphical abstract illustrates the novel ZFP36L1–CAMK2A regulatory axis in chronic rhinosinusitis (CRS) pathogenesis: 1. Molecular initiation: In nasal epithelial cells, the RNA‐binding protein ZFP36L1 (upregulated in CRS) directly binds to AU‐rich elements (AREs) in the 3′‐untranslated region (3′‐UTR) of CAMK2A mRNA, promoting its degradation and
Jiayi Xiong, Shihan Zhang, Chunhua Li, Yufeng Ai, Xinru Liu, Yuxiang Liu, Hongbing Liu   +6 more
wiley   +1 more source